Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?

by Rebecca J. Thompson, Ian Sayers, Katja Kuokkanen, Ian P. Hall
Published 2021-05-01

Human bronchial epithelial cells from patients with asthma have an altered gene expression profile

by Sangita Bhaker, Michael A. Portelli, Kamini Rakkar, Dominick Shaw, Simon Johnson, Christopher Brightling, Ian Sayers
Published 2022-02-01

Defining a role for lung function associated gene GSTCD in cell homeostasis

by Amanda P. Henry, Kelly Probert, Ceri E. Stewart, Dhruma Thakker, Sangita Bhaker, Sheyda Azimi, Ian P. Hall, Ian Sayers
Published 2019-08-01

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank

by Katherine A. Fawcett, German Demidov, Nick Shrine, Megan L. Paynton, Stephan Ossowski, Ian Sayers, Louise V. Wain, Edward J. Hollox
Published 2022-05-01

Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity

by Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers
Published 2023-10-01

Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid [version 1; referees: 2 approved]

by Tracy L Rimington, Emily Hodge, Charlotte K Billington, Sangita Bhaker, Binaya K C, Iain Kilty, Scott Jelinsky, Ian P Hall, Ian Sayers
Published 2017-04-01

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls.

by María Soler Artigas, Louise V Wain, Nick Shrine, Tricia M McKeever, UK BiLEVE, Ian Sayers, Ian P Hall, Martin D Tobin
Published 2017-01-01

Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity

by Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers
Published 2021-01-01

Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice.

by Bo Liu, Amanda P Henry, Sheyda Azimi, Suzanne Miller, Frank K Lee, Jane C Lee, Kelly Probert, Michael I Kotlikoff, Ian Sayers, Ian P Hall
Published 2019-01-01

Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma.

by Louise V Wain, Linda Odenthal-Hesse, Razan Abujaber, Ian Sayers, Caroline Beardsmore, Erol A Gaillard, Sally Chappell, Cristian M Dogaru, Tricia McKeever, Tamar Guetta-Baranes, Noor Kalsheker, Claudia E Kuehni, Ian P Hall, Martin D Tobin, Edward J Hollox
Published 2014-01-01

Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo.

by Henk Koning, Antoon J M van Oosterhout, Uilke Brouwer, Lisette E den Boef, Renée Gras, Marjan Reinders-Luinge, Corry-Anke Brandsma, Marco van der Toorn, Machteld N Hylkema, Brigitte W M Willemse, Ian Sayers, Gerard H Koppelman, Martijn C Nawijn
Published 2014-01-01

GSTCD and INTS12 regulation and expression in the human lung.

by Ma'en Obeidat, Suzanne Miller, Kelly Probert, Charlotte K Billington, Amanda P Henry, Emily Hodge, Carl P Nelson, Ceri E Stewart, Caroline Swan, Louise V Wain, María Soler Artigas, Erik Melén, Kevin Ushey, Ke Hao, Maxime Lamontagne, Yohan Bossé, Dirkje S Postma, Martin D Tobin, Ian Sayers, Ian P Hall
Published 2013-01-01

The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.

by Suzanne Miller, Amanda P Henry, Emily Hodge, Alexander K Kheirallah, Charlotte K Billington, Tracy L Rimington, Sangita K Bhaker, Ma'en Obeidat, Erik Melén, Simon K Merid, Caroline Swan, Catherine Gowland, Carl P Nelson, Ceri E Stewart, Charlotte E Bolton, Iain Kilty, Anders Malarstig, Stuart G Parker, Miriam F Moffatt, Andrew J Wardlaw, Ian P Hall, Ian Sayers
Published 2016-01-01

Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.

by Louise V Wain, Ian Sayers, María Soler Artigas, Michael A Portelli, Eleftheria Zeggini, Ma'en Obeidat, Don D Sin, Yohan Bossé, David Nickle, Corry-Anke Brandsma, Anders Malarstig, Ciara Vangjeli, Scott A Jelinsky, Sally John, Iain Kilty, Tricia McKeever, Nick R G Shrine, James P Cook, Shrina Patel, Tim D Spector, Edward J Hollox, Ian P Hall, Martin D Tobin
Published 2014-05-01

Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis

by Beatriz Guillen-Guio, Megan L. Paynton, Richard J. Allen, Daniel P.W. Chin, Lauren J. Donoghue, Amy Stockwell, Olivia C. Leavy, Tamara Hernandez-Beeftink, Carl Reynolds, Paul Cullinan, Fernando Martinez, Helen L. Booth, William A. Fahy, Ian P. Hall, Simon P. Hart, Mike R. Hill, Nik Hirani, Richard B. Hubbard, Robin J. McAnulty, Ann B. Millar, Vidya Navaratnam, Eunice Oballa, Helen Parfrey, Gauri Saini, Ian Sayers, Martin D. Tobin, Moira K.B. Whyte, Ayodeji Adegunsoye, Naftali Kaminski, Shwu-Fan Ma, Mary E. Strek, Yingze Zhang, Tasha E. Fingerlin, Maria Molina-Molina, Margaret Neighbors, X. Rebecca Sheng, Justin M. Oldham, Toby M. Maher, Philip L. Molyneaux, Carlos Flores, Imre Noth, David A. Schwartz, Brian L. Yaspan, R. Gisli Jenkins, Louise V. Wain, Edward J. Hollox
Published 2024-02-01

A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample.

by Ma'en Obeidat, Louise V Wain, Nick Shrine, Noor Kalsheker, Maria Soler Artigas, Emmanouela Repapi, Paul R Burton, Toby Johnson, Adaikalavan Ramasamy, Jing Hua Zhao, Guangju Zhai, Jennifer E Huffman, Veronique Vitart, Eva Albrecht, Wilmar Igl, Anna-Liisa Hartikainen, Anneli Pouta, Gemma Cadby, Jennie Hui, Lyle J Palmer, David Hadley, Wendy L McArdle, Alicja R Rudnicka, Inês Barroso, Ruth J F Loos, Nicholas J Wareham, Massimo Mangino, Nicole Soranzo, Tim D Spector, Sven Gläser, Georg Homuth, Henry Völzke, Panos Deloukas, Raquel Granell, John Henderson, Ivica Grkovic, Stipan Jankovic, Lina Zgaga, Ozren Polašek, Igor Rudan, Alan F Wright, Harry Campbell, Sarah H Wild, James F Wilson, Joachim Heinrich, Medea Imboden, Nicole M Probst-Hensch, Ulf Gyllensten, Åsa Johansson, Ghazal Zaboli, Linda Mustelin, Taina Rantanen, Ida Surakka, Jaakko Kaprio, Marjo-Riitta Jarvelin, Caroline Hayward, David M Evans, Beate Koch, Arthur William Musk, Paul Elliott, David P Strachan, Martin D Tobin, Ian Sayers, Ian P Hall, SpiroMeta Consortium
Published 2011-01-01