Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection?

by Michael D. Stutz, Michael D. Stutz, Samar Ojaimi, Samar Ojaimi, Gregor Ebert, Gregor Ebert, Marc Pellegrini, Marc Pellegrini
Published 2018-05-01

Virology Downunder, a meeting commentary from the 2019 Lorne Infection and Immunity Conference, Australia

by Gregor Ebert, Prasad N. Paradkar, Sarah L. Londrigan
Published 2019-09-01

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo

by Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert
Published 2020-08-01

A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6.

by Remy Robert, Laurent Juglair, Ee X Lim, Caroline Ang, Carl J H Wang, Gregor Ebert, Olan Dolezal, Charles R Mackay
Published 2017-01-01

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

by Bang Manh Tran, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Hoanh Tran, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan
Published 2020-05-01

Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting

by Christoph Gruber, Lea Krautner, Valter Bergant, Vincent Grass, Zhe Ma, Lara Rheinemann, Ariane Krus, Friederike Reinhardt, Lyupka Mazneykova, Marianne Rocha-Hasler, Dong-Jiunn Jeffery Truong, Gil Gregor Westmeyer, Andreas Pichlmair, Gregor Ebert, Florian Giesert, Wolfgang Wurst
Published 2024-04-01

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

by Swarna L. Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S. Simpson, Gregor Ebert, Angelina Vince, Marco J. Herold, Andrew Kueh, Jaclyn S. Pearson, Laura F. Dagley, James M. Murphy, Andrew I. Webb, Kate E. Lawlor, James E. Vince
Published 2021-05-01

Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models

by Michelle P. Clark, Thao Huynh, Shringar Rao, Liana Mackiewicz, Hugh Mason, Shahla Romal, Michael D. Stutz, Sang H. Ahn, Linda Earnest, Vitina Sozzi, Margaret Littlejohn, Bang M. Tran, Norbert Wiedemann, Elizabeth Vincan, Joseph Torresi, Hans J. Netter, Tokameh Mahmoudi, Peter Revill, Marc Pellegrini, Gregor Ebert
Published 2021-06-01

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

by Daniel Frank, Sarah E. Garnish, Jarrod J. Sandow, Ashley Weir, Lin Liu, Elise Clayer, Lizeth Meza, Maryam Rashidi, Simon A. Cobbold, Simon R. Scutts, Marcel Doerflinger, Holly Anderton, Kate E. Lawlor, Najoua Lalaoui, Andrew J. Kueh, Vik Ven Eng, Rebecca L. Ambrose, Marco J. Herold, Andre L. Samson, Rebecca Feltham, James M. Murphy, Gregor Ebert, Jaclyn S. Pearson, James E. Vince
Published 2022-07-01

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

by Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria E. Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Matthew Cook, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, André L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand
Published 2023-09-01

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

by Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C. Chüeh, Judy Doherty, François Vaillant, Gwo-Yaw Ho, Matthew J. Wakefield, Clare E. Weeden, Alvin Kamili, Jayne Murray, Sela T. Po’uha, Janet Weinstock, Serena R. Kane, Maree C. Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J. Kershaw, Chin Wee Tan, Helen M. Witchard, Gregor Ebert, Susan A. Charman, Ian Street, Maria Kavallaris, Michelle Haber, Jamie I. Fletcher, Marie-Liesse Asselin-Labat, Clare L. Scott, Jane E. Visvader, Geoffrey J. Lindeman, Keith G. Watson, Antony W. Burgess, Guillaume Lessene
Published 2021-03-01

Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections

by Patrick Y. A. Reinke, Edmarcia Elisa de Souza, Sebastian Günther, Sven Falke, Julia Lieske, Wiebke Ewert, Jure Loboda, Alexander Herrmann, Aida Rahmani Mashhour, Katarina Karničar, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Viviane Fongaro Botosso, Gláucia Maria Machado Santelli, Josana Kapronezai, Marcelo Valdemir de Araújo, Taiana Tainá Silva-Pereira, Antônio Francisco de Souza Filho, Mariana Silva Tavares, Lizdany Flórez-Álvarez, Danielle Bruna Leal de Oliveira, Edison Luiz Durigon, Paula Roberta Giaretta, Marcos Bryan Heinemann, Maurice Hauser, Brandon Seychell, Hendrik Böhler, Wioletta Rut, Marcin Drag, Tobias Beck, Russell Cox, Henry N. Chapman, Christian Betzel, Wolfgang Brehm, Winfried Hinrichs, Gregor Ebert, Sharissa L. Latham, Ana Marcia de Sá Guimarães, Dusan Turk, Carsten Wrenger, Alke Meents
Published 2023-10-01