Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

by Lotte B. Romijn, Axel A. Almet, Chin Wee Tan, James M. Osborne
Published 2020-03-01

Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts.

by Hon Yan Kelvin Yip, Chin Wee Tan, Yumiko Hirokawa, Antony Wilks Burgess
Published 2018-01-01

Colon cryptogenesis: asymmetric budding.

by Chin Wee Tan, Yumiko Hirokawa, Bruce S Gardiner, David W Smith, Antony W Burgess
Published 2013-01-01

Dissection of the bone marrow microenvironment in hairy cell leukaemia identifies prognostic tumour and immune related biomarkers

by Rachel M. Koldej, Ashvind Prabahran, Chin Wee Tan, Ashley P. Ng, Melissa J. Davis, David S. Ritchie
Published 2021-09-01

Wnt signalling pathway parameters for mammalian cells.

by Chin Wee Tan, Bruce S Gardiner, Yumiko Hirokawa, Meredith J Layton, David W Smith, Antony W Burgess
Published 2012-01-01

Exploring the Singapore general population’s trust in COVID-19 information from different sources and its association with perceived risk of infection during the pandemic

by Fiona Devi, Bernard Chin Wee Tan, Saleha Shafie, Yun Jue Zhang, Shazana Shahwan, Pratika Satghare, Siow Ann Chong, Mythily Subramaniam
Published 2024-06-01

Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components.

by Bruce S Gardiner, Kelvin K L Wong, Grand R Joldes, Addison J Rich, Chin Wee Tan, Antony W Burgess, David W Smith
Published 2015-10-01

Spatial proteomics identifies a spectrum of immune dysregulation in acquired bone marrow failure syndromes

by Rachel M. Koldej, Rachel M. Koldej, Ashvind Prabahran, Ashvind Prabahran, Ashvind Prabahran, Chin Wee Tan, Chin Wee Tan, Mandy Ludford-Menting, Mandy Ludford-Menting, Huw Morgan, Huw Morgan, Nicholas Holzwart, Nicholas Holzwart, Melissa J. Davis, Melissa J. Davis, Melissa J. Davis, David S. Ritchie, David S. Ritchie, David S. Ritchie
Published 2023-09-01

vissE: a versatile tool to identify and visualise higher-order molecular phenotypes from functional enrichment analysis

by Dharmesh D. Bhuva, Chin Wee Tan, Ning Liu, Holly J. Whitfield, Nicholas Papachristos, Samuel C. Lee, Malvika Kharbanda, Ahmed Mohamed, Melissa J. Davis
Published 2024-02-01

Compartmentalized spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma identifies immune checkpoint molecules and tumor necrosis factor receptor...

by Habib Sadeghirad, Ning Liu, Ning Liu, James Monkman, Ning Ma, Bassem Ben Cheikh, Niyati Jhaveri, Chin Wee Tan, Chin Wee Tan, Majid Ebrahimi Warkiani, Mark N. Adams, Mark N. Adams, Quan Nguyen, Rahul Ladwa, Rahul Ladwa, Oliver Braubach, Ken O’Byrne, Ken O’Byrne, Ken O’Byrne, Melissa Davis, Melissa Davis, Melissa Davis, Melissa Davis, Brett G. M. Hughes, Brett G. M. Hughes, Arutha Kulasinghe
Published 2023-04-01

A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

by Michael Buchert, Franziska Rohde, Moritz Eissmann, Niall Tebbutt, Ben Williams, Chin Wee Tan, Alexander Owen, Yumiko Hirokawa, Alexandra Gnann, Gertraud Orend, Gayle Orner, Rod H. Dashwood, Joan K. Heath, Matthias Ernst, Klaus-Peter Janssen
Published 2015-11-01

Low-viscosity matrix suspension culture enables scalable analysis of patient-derived organoids and tumoroids from the large intestine

by Yumiko Hirokawa, Jordan Clarke, Michelle Palmieri, Tao Tan, Dmitri Mouradov, Shan Li, Cong Lin, Fuqiang Li, Huijuan Luo, Kui Wu, Maree Faux, Chin Wee Tan, Margaret Lee, Grace Gard, Peter Gibbs, Antony W. Burgess, Oliver M. Sieber
Published 2021-09-01

Transplantable programmed death ligand 1 expressing gastroids from gastric cancer prone Nfkb1 −/− mice

by Jun T. Low, Gwo-Yaw Ho, Mark Scott, Chin Wee Tan, Lachlan Whitehead, Kathy Barber, Hon Y. K. Yip, Johanna F. Dekkers, Yumiko Hirokawa, John Silke, Antony W. Burgess, Andreas Strasser, Tracy L. Putoczki, Lorraine A. O’Reilly
Published 2021-11-01

Library size confounds biology in spatial transcriptomics data

by Dharmesh D. Bhuva, Chin Wee Tan, Agus Salim, Claire Marceaux, Marie A. Pickering, Jinjin Chen, Malvika Kharbanda, Xinyi Jin, Ning Liu, Kristen Feher, Givanna Putri, Wayne D. Tilley, Theresa E. Hickey, Marie-Liesse Asselin-Labat, Belinda Phipson, Melissa J. Davis
Published 2024-04-01

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

by Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand
Published 2019-04-01

In situ single-cell profiling sheds light on IFI27 localisation during SARS-CoV-2 infection

by Chin Wee Tan, Jinjin Chen, Ning Liu, Dharmesh D. Bhuva, Tony Blick, James Monkman, Caroline Cooper, Malvika Kharbanda, Kristen Feher, Belinda Phipson, Emily E. Killingbeck, Liuliu Pan, Youngmi Kim, Yan Liang, Andy Nam, Michael Leon, Paulo Souza-Fonseca-Guimaraes, Seigo Nagashima, Ana Paula Camargo Martins, Cleber Machado-Souza, Lucia de Noronha, Benjamin Tang, Kirsty Short, John Fraser, Gabrielle T. Belz, Fernando Souza-Fonseca-Guimaraes, Arutha Kulasinghe, Melissa J. Davis
Published 2024-03-01

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

by Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C. Chüeh, Judy Doherty, François Vaillant, Gwo-Yaw Ho, Matthew J. Wakefield, Clare E. Weeden, Alvin Kamili, Jayne Murray, Sela T. Po’uha, Janet Weinstock, Serena R. Kane, Maree C. Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J. Kershaw, Chin Wee Tan, Helen M. Witchard, Gregor Ebert, Susan A. Charman, Ian Street, Maria Kavallaris, Michelle Haber, Jamie I. Fletcher, Marie-Liesse Asselin-Labat, Clare L. Scott, Jane E. Visvader, Geoffrey J. Lindeman, Keith G. Watson, Antony W. Burgess, Guillaume Lessene
Published 2021-03-01

IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study

by Maryam Shojaei, Maryam Shojaei, Maryam Shojaei, Amir Shamshirian, James Monkman, Laura Grice, Laura Grice, Minh Tran, Chin Wee Tan, Chin Wee Tan, Siok Min Teo, Gustavo Rodrigues Rossi, Timothy R. McCulloch, Marek Nalos, Maedeh Raei, Alireza Razavi, Roya Ghasemian, Mobina Gheibi, Fatemeh Roozbeh, Peter D. Sly, Kirsten M. Spann, Keng Yih Chew, Yanshan Zhu, Yao Xia, Timothy J. Wells, Alexandra Cristina Senegaglia, Alexandra Cristina Senegaglia, Carmen Lúcia Kuniyoshi, Carmen Lúcia Kuniyoshi, Claudio Luciano Franck, Anna Flavia Ribeiro dos Santos, Lucia de Noronha, Sepideh Motamen, Reza Valadan, Reza Valadan, Omolbanin Amjadi, Rajan Gogna, Rajan Gogna, Esha Madan, Reza Alizadeh-Navaei, Liliana Lamperti, Felipe Zuñiga, Estefania Nova-Lamperti, Gonzalo Labarca, Gonzalo Labarca, Ben Knippenberg, Velma Herwanto, Ya Wang, Ya Wang, Ya Wang, Amy Phu, Amy Phu, Tracy Chew, Timothy Kwan, Karan Kim, Sally Teoh, Tiana M. Pelaia, Win Sen Kuan, Win Sen Kuan, Yvette Jee, Jon Iredell, Jon Iredell, Jon Iredell, Ken O’Byrne, John F. Fraser, Melissa J. Davis, Melissa J. Davis, Melissa J. Davis, Gabrielle T. Belz, Majid E. Warkiani, Carlos Salomon Gallo, Carlos Salomon Gallo, Fernando Souza-Fonseca-Guimaraes, Quan Nguyen, Anthony Mclean, Arutha Kulasinghe, Kirsty R. Short, Benjamin Tang, Benjamin Tang
Published 2023-01-01