Gordon Freeman

Gordon Freeman is the silent protagonist of the ''Half-Life'' video game series, created by Gabe Newell and designed by Marc Laidlaw of Valve. His first appearance is in ''Half-Life'' (1998). Gordon is depicted as a bespectacled white man from Seattle, with brown hair and a signature circle beard, who graduated from MIT with a PhD in theoretical physics. He was an employee at the fictional Black Mesa Research Facility. Controlled by the player, Gordon is often tasked with using a wide range of weapons and tools to fight alien creatures such as headcrabs, as well as Combine machines and soldiers. Gordon's character has been well received by critics and gamers, and various gaming websites often consider him to be one of the greatest video game characters of all time, including UGO and ''GameSpot''. Provided by Wikipedia
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    229 CX3CR1 in exhausted CD8 T cell states
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    256 The TIGIT/CD226/CD155 axis and the effects of combining PD-1/PD-L1 blockade with TIGIT-targeting antibody therapy in syngeneic murine glioblastoma models
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    808 The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances responses to anti-PD-1 immunotherapy
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    442 CAIX targeted CAR-T cells exhibited antitumor efficacy on renal cell carcinoma (RCC) patient derived organotypic tumor spheroids (PDOTS)
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    700 Increasing MHC-I expression to potentiate immune checkpoint blockade therapy
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