SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site

by Allen, Mark D., Freund, Stefan M. V., Bycroft, Mark, Zinzalla, Giovanna
Published 2021

Molecular Basis for Modulation of the p53 Target Selectivity by KLF4

by Brandt, Tobias, Townsley, Fiona M., Teufel, Daniel P., Freund, Stefan M. V., Veprintsev, Dmitry B.
Published 2012

Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation

by Biggs, George S., Klein, Oskar James, Maslen, Sarah L., Skehel, J. Mark, Rutherford, Trevor J., Freund, Stefan M. V., Hollfelder, Florian, Boss, Sally R., Barker, Paul D.
Published 2021

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

by Mevissen, Tycho E.T., Hospenthal, Manuela; id_orcid0000-0003-1175-6826, Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Published 2013

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.

by Heimhalt, Maren, Berndt, Alex, Wagstaff, Jane, Anandapadamanaban, Madhanagopal, Perisic, Olga, Maslen, Sarah, McLaughlin, Stephen, Yu, Conny Wing-Heng, Masson, Glenn R, Boland, Andreas, Ni, Xiaodan, Yamashita, Keitaro, Murshudov, Garib N, Skehel, Mark, Freund, Stefan M, Williams, Roger L
Published 2021

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid

by De la Roche, Marc, Rutherford, Trevor J., Gupta, Deepti, Veprintsev, Dmitry B., Saxty, Barbara, Freund, Stefan M., Bienz, Mariann
Published 2012

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

by Douse, Christopher H., Tchasovnikarova, Iva A., Timms, Richard T., Protasio, Anna V., Seczynska, Marta, Prigozhin, Daniil M., Albecka, Anna, Wagstaff, Jane, Williamson, James C., Freund, Stefan M. V., Lehner, Paul J., Modis, Yorgo
Published 2020

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

by Douse, Christopher H., Tchasovnikarova, Iva A., Timms, Richard T., Protasio, Anna V., Seczynska, Marta, Prigozhin, Daniil M., Albecka, Anna, Wagstaff, Jane, Williamson, James C., Freund, Stefan M. V., Lehner, Paul J., Modis, Yorgo
Published 2021

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.

by de la Roche, Marc, Rutherford, Trevor J, Gupta, Deepti, Veprintsev, Dmitry B, Saxty, Barbara, Freund, Stefan M, Bienz, Mariann
Published 2019