Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.

by Heimhalt, Maren, Berndt, Alex, Wagstaff, Jane, Anandapadamanaban, Madhanagopal, Perisic, Olga, Maslen, Sarah, McLaughlin, Stephen, Yu, Conny Wing-Heng, Masson, Glenn R, Boland, Andreas, Ni, Xiaodan, Yamashita, Keitaro, Murshudov, Garib N, Skehel, Mark, Freund, Stefan M, Williams, Roger L
Published 2021

A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.

by Kiss, Leo, Zeng, Jingwei, Dickson, Claire F, Mallery, Donna L, Yang, Ji-Chun, McLaughlin, Stephen H, Boland, Andreas, Neuhaus, David, James, Leo C
Published 2020

Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

by Chang, Leifu, Yang, Jing, Jo, Chang Hwa, Boland, Andreas, Zhang, Ziguo, McLaughlin, Stephen H., Abu-Thuraia, Afnan, Killoran, Ryan C., Smith, Matthew J., Côté, Jean-Francois, Barford, David
Published 2021

Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

by Chang, Leifu, Yang, Jing, Jo, Chang Hwa, Boland, Andreas, Zhang, Ziguo, McLaughlin, Stephen H., Abu-Thuraia, Afnan, Killoran, Ryan C., Smith, Matthew J., Côté, Jean-Francois, Barford, David
Published 2020