Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma

by Wei Ni, Zirong Chen, Xin Zhou, Rongqiang Yang, Mu Yu, Jianrong Lu, Frederic J. Kaye, Lizi Wu
Published 2021-01-01

PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer

by Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J. Kaye, Guangrong Zheng, Daohong Zhou
Published 2024-03-01

Disparities Contributing to Late-Stage Diagnosis of Lung, Colorectal, Breast, and Cervical Cancers: Rural and Urban Poverty in Florida

by Jaclyn M. Hall, Rahma S. Mkuu, Hee Deok Cho, Jennifer N. Woodard, Frederic J. Kaye, Jiang Bian, Elizabeth A. Shenkman, Yi Guo
Published 2023-10-01

Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming—A New Mechanism for SCLC Chemoresistance Boosted by Nicotine

by Yuzhi Wang, Tengfei Bian, Lina Song, Yunhan Jiang, Zhiguang Huo, Ramzi G. Salloum, Graham W. Warren, Frederic J. Kaye, Naomi Fujioka, Lingtao Jin, Chengguo Xing
Published 2022-05-01

Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

by Xin Zhou, Jennifer W Li, Zirong Chen, Wei Ni, Xuehui Li, Rongqiang Yang, Huangxuan Shen, Jian Liu, Francesco J DeMayo, Jianrong Lu, Frederic J Kaye, Lizi Wu
Published 2021-06-01

BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers

by Sajid Khan, Janet Wiegand, Peiyi Zhang, Wanyi Hu, Dinesh Thummuri, Vivekananda Budamagunta, Nan Hua, Lingtao Jin, Carmen J. Allegra, Scott E. Kopetz, Maria Zajac-Kaye, Frederic J. Kaye, Guangrong Zheng, Daohong Zhou
Published 2022-03-01

Nivolumab monotherapy or combination with ipilimumab with or without cobimetinib in previously treated patients with pancreatic adenocarcinoma (CheckMate 032)

by Padmanee Sharma, Asim Amin, Dung T Le, Michael A Morse, Marina Tschaika, Matthew H Taylor, Margaret Callahan, Katriina J Peltola, Frederic J Kaye, Eileen M O'Reilly, Stephanie Meadows Shropshire, Shaun O'Brien
Published 2024-02-01

Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational...

by Yi Guo, Dongyu Zhang, Rafael Meza, Jihyoun Jeon, Dejana Braithwaite, Gerard A Silvestri, Michael K Gould, Jiang Bian, Bruno Hochhegger, Shama D Karanth, Christopher G Slatore, Martin Tammemagi, Mattthew Schabath, Meghann Wheeler, Frederic J Kaye
Published 2022-06-01

The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma

by Zirong Chen, Wei Ni, Jian-Liang Li, Shuibin Lin, Xin Zhou, Yuping Sun, Jennifer W. Li, Marino E. Leon, Maria D. Hurtado, Sergei Zolotukhin, Chen Liu, Jianrong Lu, James D. Griffin, Frederic J. Kaye, Lizi Wu
Published 2021-04-01

Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival

by Vinod Vijayakurup, Kyungah Maeng, Hye Seung Lee, Benjamin Meyer, Sandra Burkett, Akbar Nawab, Michael W. Dougherty, Christian Jobin, Iqbal Mahmud, Timothy J. Garrett, Michael Feely, Kyoung Bun Lee, Frederic J. Kaye, Maria V. Guijarro, Maria Zajac-Kaye
Published 2022-10-01

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

by Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri, Janet Wiegand, Peiyi Zhang, Xuan Zhang, Vivekananda Budamagunta, Nan Hua, Yang Yang, Umasankar De, Lingtao Jin, Weizhou Zhang, Guangrong Zheng, Robert Hromas, Christine Hann, Maria Zajac-Kaye, Frederic J. Kaye, Daohong Zhou
Published 2023-01-01

First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival

by Maria V. Guijarro, Patrick C. Kellish, Peter E. Dib, Nicholas G. Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicholas V. Borrero, Carlos Modenutti, Michael Feely, Elham Nasri, Robert P. Seifert, Xiaoping Luo, Richard L. Bennett, Daniil Shabashvili, Jonathan D. Licht, Robert McKenna, Adrian Roitberg, Robert W. Huigens III, Frederic J. Kaye, Maria Zajac-Kaye
Published 2023-05-01