Understanding the Mechanism of Recognition of Gab2 by the N-SH2 Domain of SHP2

by Lorenzo Visconti, Francesca Malagrinò, Livia Pagano, Angelo Toto
Published 2020-06-01

The Effect of Proline <i>cis</i>-<i>trans</i> Isomerization on the Folding of the C-Terminal SH2 Domain from p85

by Francesca Troilo, Francesca Malagrinò, Lorenzo Visconti, Angelo Toto, Stefano Gianni
Published 2019-12-01

Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G

by Livia Pagano, Francesca Malagrinò, Caterina Nardella, Stefano Gianni, Angelo Toto
Published 2021-12-01

Unveiling the Molecular Basis of the Noonan Syndrome-Causing Mutation T42A of SHP2

by Angelo Toto, Francesca Malagrinò, Lorenzo Visconti, Francesca Troilo, Stefano Gianni
Published 2020-01-01

Understanding the Binding Induced Folding of Intrinsically Disordered Proteins by Protein Engineering: Caveats and Pitfalls

by Francesca Malagrinò, Lorenzo Visconti, Livia Pagano, Angelo Toto, Francesca Troilo, Stefano Gianni
Published 2020-05-01

Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery

by Livia Pagano, Angelo Toto, Francesca Malagrinò, Lorenzo Visconti, Per Jemth, Stefano Gianni
Published 2021-01-01

Demonstration of Binding Induced Structural Plasticity in a SH2 Domain

by Lorenzo Visconti, Angelo Toto, James A. Jarvis, Francesca Troilo, Francesca Malagrinò, Alfonso De Simone, Stefano Gianni
Published 2020-05-01

On the Effects of Disordered Tails, Supertertiary Structure and Quinary Interactions on the Folding and Function of Protein Domains

by Francesca Malagrinò, Valeria Pennacchietti, Daniele Santorelli, Livia Pagano, Caterina Nardella, Awa Diop, Angelo Toto, Stefano Gianni
Published 2022-01-01

Folding and Binding Kinetics of the Tandem of SH2 Domains from SHP2

by Livia Pagano, Valeria Pennacchietti, Francesca Malagrinò, Mariana Di Felice, Julian Toso, Elena Puglisi, Stefano Gianni, Angelo Toto
Published 2024-06-01

Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State

by Lorenzo Visconti, Francesca Malagrinò, Luca Broggini, Chiara Maria Giulia De Luca, Fabio Moda, Stefano Gianni, Stefano Ricagno, Angelo Toto
Published 2019-01-01

<i>N</i>-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells

by Karim Zuhra, Catarina S. Tomé, Letizia Masi, Giorgio Giardina, Giulia Paulini, Francesca Malagrinò, Elena Forte, João B. Vicente, Alessandro Giuffrè
Published 2019-08-01

SH2 Domains: Folding, Binding and Therapeutical Approaches

by Awa Diop, Daniele Santorelli, Francesca Malagrinò, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Lucia Marcocci, Paola Pietrangeli, Stefano Gianni, Angelo Toto
Published 2022-12-01

Folding and Binding Mechanisms of the SH2 Domain from Crkl

by Caterina Nardella, Angelo Toto, Daniele Santorelli, Livia Pagano, Awa Diop, Valeria Pennacchietti, Paola Pietrangeli, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni
Published 2022-07-01

Addressing the Binding Mechanism of the Meprin and TRAF-C Homology Domain of the Speckle-Type POZ Protein Using Protein Engineering

by Awa Diop, Paola Pietrangeli, Valeria Pennacchietti, Livia Pagano, Angelo Toto, Mariana Di Felice, Sara Di Matteo, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni
Published 2023-12-01

Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

by Caterina Nardella, Lorenzo Visconti, Francesca Malagrinò, Livia Pagano, Marianna Bufano, Marianna Nalli, Antonio Coluccia, Giuseppe La Regina, Romano Silvestri, Stefano Gianni, Angelo Toto
Published 2021-10-01

Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners

by Awa Diop, Paola Pietrangeli, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Angelo Toto, Mariana Di Felice, Sara Di Matteo, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni
Published 2023-06-01

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2

by Francesca Malagrinò, Antonio Coluccia, Marianna Bufano, Giuseppe La Regina, Michela Puxeddu, Angelo Toto, Lorenzo Visconti, Alessio Paone, Maria Chiara Magnifico, Francesca Troilo, Francesca Cutruzzolà, Romano Silvestri, Stefano Gianni
Published 2020-11-01