Dendritic Cells or Macrophages? The Microenvironment of Human Clear Cell Renal Cell Carcinoma Imprints a Mosaic Myeloid Subtype Associated with Patient Survival

by Dorothee Brech, Anna S. Herbstritt, Sarah Diederich, Tobias Straub, Evangelos Kokolakis, Martin Irmler, Johannes Beckers, Florian A. Büttner, Elke Schaeffeler, Stefan Winter, Matthias Schwab, Peter J. Nelson, Elfriede Noessner
Published 2022-10-01

Bioengineered Pancreas–Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia

by Reza Zandi Shafagh, Sonia Youhanna, Jibbe Keulen, Joanne X. Shen, Nayere Taebnia, Lena C. Preiss, Kathrin Klein, Florian A. Büttner, Mikael Bergqvist, Wouter van derWijngaart, Volker M. Lauschke
Published 2022-12-01

Characterization of Genetic Heterogeneity in Recurrent Metastases of Renal Cell Carcinoma

by Carolin Sauter-Meyerhoff, Regina Bohnert, Pascale Mazzola, Viktoria Stühler, Siarhei Kandabarau, Florian A. Büttner, Stefan Winter, Lisa Herrmann, Steffen Rausch, Jörg Hennenlotter, Falko Fend, Marcus Scharpf, Arnulf Stenzl, Stephan Ossowski, Jens Bedke, Matthias Schwab, Elke Schaeffeler
Published 2021-12-01

Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma

by Anna Reustle, Lena‐Sophie Menig, Patrick Leuthold, Ute Hofmann, Viktoria Stühler, Christian Schmees, Michael Becker, Mathias Haag, Verena Klumpp, Stefan Winter, Florian A. Büttner, Steffen Rausch, Jörg Hennenlotter, Falko Fend, Marcus Scharpf, Arnulf Stenzl, Jens Bedke, Matthias Schwab, Elke Schaeffeler
Published 2022-06-01

Hepatic Expression of the Na⁺-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

by Roman Tremmel, Anne T. Nies, Barbara A. C. van Eijck, Niklas Handin, Mathias Haag, Stefan Winter, Florian A. Büttner, Charlotte Kölz, Franziska Klein, Pascale Mazzola, Ute Hofmann, Kathrin Klein, Per Hoffmann, Markus M. Nöthen, Fabienne Z. Gaugaz, Per Artursson, Matthias Schwab, Elke Schaeffeler
Published 2022-07-01

A Molecularly Characterized Preclinical Platform of Subcutaneous Renal Cell Carcinoma (RCC) Patient-Derived Xenograft Models to Evaluate Novel Treatment Strategies

by Dennis Gürgen, Michael Becker, Mathias Dahlmann, Susanne Flechsig, Elke Schaeffeler, Elke Schaeffeler, Elke Schaeffeler, Florian A. Büttner, Christian Schmees, Regina Bohnert, Jens Bedke, Jens Bedke, Matthias Schwab, Matthias Schwab, Matthias Schwab, Matthias Schwab, Johann J. Wendler, Martin Schostak, Burkhard Jandrig, Wolfgang Walther, Wolfgang Walther, Wolfgang Walther, Jens Hoffmann
Published 2022-06-01

mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming

by Helmut Bischof, Selina Maier, Piotr Koprowski, Bogusz Kulawiak, Sandra Burgstaller, Joanna Jasińska, Kristian Serafimov, Monika Zochowska, Dominic Gross, Werner Schroth, Lucas Matt, David Arturo Juarez Lopez, Ying Zhang, Irina Bonzheim, Florian A Büttner, Falko Fend, Matthias Schwab, Andreas L Birkenfeld, Roland Malli, Michael Lämmerhofer, Piotr Bednarczyk, Adam Szewczyk, Robert Lukowski
Published 2024-05-01

A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy

by Florian A. Büttner, Stefan Winter, Viktoria Stühler, Steffen Rausch, Jörg Hennenlotter, Susanne Füssel, Stefan Zastrow, Matthias Meinhardt, Marieta Toma, Carmen Jerónimo, Rui Henrique, Vera Miranda-Gonçalves, Nils Kröger, Silvia Ribback, Arndt Hartmann, Abbas Agaimy, Christine Stöhr, Iris Polifka, Falko Fend, Marcus Scharpf, Eva Comperat, Gabriel Wasinger, Holger Moch, Arnulf Stenzl, Marco Gerlinger, Jens Bedke, Matthias Schwab, Elke Schaeffeler
Published 2022-09-01