Eltrombopag directly inhibits BAX and prevents cell death

by Adam Z. Spitz, Emmanouil Zacharioudakis, Denis E. Reyna, Thomas P. Garner, Evripidis Gavathiotis
Published 2021-02-01

Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis

by Nadege Gitego, Bogos Agianian, Oi Wei Mak, Vasantha Kumar MV, Emily H. Cheng, Evripidis Gavathiotis
Published 2023-12-01

Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells

by Jinzhong Zhang, Jing He, Jennifer L. Johnson, Farhana Rahman, Evripidis Gavathiotis, Ana Maria Cuervo, Sergio D. Catz
Published 2019-02-01

Acetophenone protection against cisplatin-induced end-organ damage

by Brian Geohagen, Elizabeth Zeldin, Kimberly Reidy, Tao Wang, Evripidis Gavathiotis, Yonatan I. Fishman, Richard LoPachin, David M. Loeb, Daniel A. Weiser
Published 2023-01-01

Inhibitors of BRAF dimers using an allosteric site

by Xiomaris M. Cotto-Rios, Bogos Agianian, Nadege Gitego, Emmanouil Zacharioudakis, Orsi Giricz, Yang Wu, Yiyu Zou, Amit Verma, Poulikos I. Poulikakos, Evripidis Gavathiotis
Published 2020-09-01

Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer

by Andrea Lopez, Denis E. Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A. Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos, Evripidis Gavathiotis
Published 2022-03-01

Marinopyrrole Derivatives with Sulfide Spacers as Selective Disruptors of Mcl-1 Binding to Pro-Apoptotic Protein Bim

by Chunwei Cheng, Yan Liu, Maria E. Balasis, Thomas P. Garner, Jerry Li, Nicholas L. Simmons, Norbert Berndt, Hao Song, Lili Pan, Yong Qin, K. C. Nicolaou, Evripidis Gavathiotis, Said M. Sebti, Rongshi Li
Published 2014-07-01

Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration

by Raquel Gomez-Sintes, Qisheng Xin, Juan Ignacio Jimenez-Loygorri, Mericka McCabe, Antonio Diaz, Thomas P. Garner, Xiomaris M. Cotto-Rios, Yang Wu, Shuxian Dong, Cara A. Reynolds, Bindi Patel, Pedro de la Villa, Fernando Macian, Patricia Boya, Evripidis Gavathiotis, Ana Maria Cuervo
Published 2022-07-01

Modulating mitofusins to control mitochondrial function and signaling

by Emmanouil Zacharioudakis, Bogos Agianian, Vasantha Kumar MV, Nikolaos Biris, Thomas P. Garner, Inna Rabinovich-Nikitin, Amanda T. Ouchida, Victoria Margulets, Lars Ulrik Nordstrøm, Joel S. Riley, Igor Dolgalev, Yun Chen, Andre J. H. Wittig, Ryan Pekson, Chris Mathew, Peter Wei, Aristotelis Tsirigos, Stephen W. G. Tait, Lorrie A. Kirshenbaum, Richard N. Kitsis, Evripidis Gavathiotis
Published 2022-07-01

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine

by Nora E. Rahmani, Nandini Ramachandra, Srabani Sahu, Nadege Gitego, Andrea Lopez, Kith Pradhan, Tushar D. Bhagat, Shanisha Gordon-Mitchell, Bianca Rivera Pena, Mohammad Kazemi, Keshav Rao, Orsi Giricz, Shahina Bano Maqbool, Raul Olea, Yongmei Zhao, Jinghang Zhang, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Juseong Lee, Tianyu Sun, Ulrich Steidl, Aditi Shastri, Daichi Inoue, Omar Abdel-Wahab, Andrea Pellagatti, Evripidis Gavathiotis, Jacqueline Boultwood, Amit Verma
Published 2021-09-01

Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations

by Gaurav S Choudhary, Andrea Pellagatti, Bogos Agianian, Molly A Smith, Tushar D Bhagat, Shanisha Gordon-Mitchell, Srabani Sahu, Sanjay Pandey, Nishi Shah, Srinivas Aluri, Ritesh Aggarwal, Sarah Aminov, Leya Schwartz, Violetta Steeples, Robert N Booher, Murali Ramachandra, Maria Samson, Milagros Carbajal, Kith Pradhan, Teresa V Bowman, Manoj M Pillai, Britta Will, Amittha Wickrema, Aditi Shastri, Robert K Bradley, Robert E Martell, Ulrich G Steidl, Evripidis Gavathiotis, Jacqueline Boultwood, Daniel T Starczynowski, Amit Verma
Published 2022-08-01