Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death

by Hannah Maria Baumert, Eric Metzger, Matthias Fahrner, Julie George, Roman K. Thomas, Oliver Schilling, Roland Schüle
Published 2020-02-01

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells.

by Jens Köhler, German Erlenkamp, Adrien Eberlin, Tobias Rumpf, Inna Slynko, Eric Metzger, Roland Schüle, Wolfgang Sippl, Manfred Jung
Published 2012-01-01

Lysine Methyltransferase 9 (KMT9) Is an Actionable Target in Muscle-Invasive Bladder Cancer

by Sainab Totonji, Anna Ramos-Triguero, Dominica Willmann, Manuela Sum, Sylvia Urban, Helena Bauer, Astrid Rieder, Sheng Wang, Holger Greschik, Eric Metzger, Roland Schüle
Published 2024-04-01

Overexpression of KMT9α Is Associated with Aggressive Basal-like Muscle-Invasive Bladder Cancer

by Florestan J. Koll, Eric Metzger, Jana Hamann, Anna Ramos-Triguero, Katrin Bankov, Jens Köllermann, Claudia Döring, Felix K. H. Chun, Roland Schüle, Peter J. Wild, Henning Reis
Published 2023-02-01

Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

by Katia Ancelin, Laurène Syx, Maud Borensztein, Noémie Ranisavljevic, Ivaylo Vassilev, Luis Briseño-Roa, Tao Liu, Eric Metzger, Nicolas Servant, Emmanuel Barillot, Chong-Jian Chen, Roland Schüle, Edith Heard
Published 2016-02-01

LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription

by Isabella Scionti, Shinichiro Hayashi, Sandrine Mouradian, Emmanuelle Girard, Joana Esteves de Lima, Véronique Morel, Thomas Simonet, Maud Wurmser, Pascal Maire, Katia Ancelin, Eric Metzger, Roland Schüle, Evelyne Goillot, Frederic Relaix, Laurent Schaeffer
Published 2017-02-01

LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice

by Qingshuang Cai, Rajesh Sahu, Vanessa Ueberschlag-Pitiot, Sirine Souali-Crespo, Céline Charvet, Ilyes Silem, Félicie Cottard, Tao Ye, Fatima Taleb, Eric Metzger, Roland Schuele, Isabelle M. L. Billas, Gilles Laverny, Daniel Metzger, Delphine Duteil
Published 2024-04-01

Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity

by Changmeng Cai, Housheng Hansen He, Shuai Gao, Sen Chen, Ziyang Yu, Yanfei Gao, Shaoyong Chen, Mei Wei Chen, Jesse Zhang, Musaddeque Ahmed, Yang Wang, Eric Metzger, Roland Schüle, X. Shirley Liu, Myles Brown, Steven P. Balk
Published 2014-12-01

Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity

by Sheng Wang, Sebastian O. Klein, Sylvia Urban, Maximilian Staudt, Nicolas P. F. Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A. Rennar, Christian Gratzke, Katrin M. Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher G. Thomson, Manfred Jung, Eric Metzger, Roland Schüle
Published 2024-01-01