Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection

by Paul Munson, Yi Liu, Debra Bratt, James T. Fuller, Xintao Hu, George N. Pavlakis, Barbara K. Felber, James I. Mullins, Deborah Heydenburg Fuller
Published 2018-07-01

Computationally engineered influenza antiviral affords broad prophylactic and therapeutic protection against influenza

by Deborah Heydenburg Fuller, Merika Treants Koday, Jorgen Nelson, Aaron Chevalier, Michael Koday, Donald F. Smee, Amy L. Hartman, Douglas S. Reed, Kelly Stefano Cole, David Baker
Published 2016-05-01

Effects of therapeutic vaccination on the control of SIV in rhesus macaques with variable responsiveness to antiretroviral drugs.

by Hillary Claire Tunggal, Paul Veness Munson, Megan Ashley O'Connor, Nika Hajari, Sandra Elizabeth Dross, Debra Bratt, James Thomas Fuller, Kenneth Bagley, Deborah Heydenburg Fuller
Published 2021-01-01

Correction: Laparoscopic Technique for Serial Collection of Para-Colonic, Left Colic, and Inferior Mesenteric Lymph Nodes in Macaques.

by Jeremy Smedley, Rhonda Macalister, Solomon Wangari, Mercy Gathuka, Joel Ahrens, Naoto Iwayama, Drew May, Debbie Bratt, Megan O'Connor, Paul Munson, Michael Koday, Lifson, Deborah Heydenburg Fuller
Published 2018-01-01

Laparoscopic Technique for Serial Collection of Para-Colonic, Left Colic, and Inferior Mesenteric Lymph Nodes in Macaques.

by Jeremy Smedley, Rhonda Macalister, Solomon Wangari, Mercy Gathuka, Joel Ahrens, Naoto Iwayama, Drew May, Debbie Bratt, Megan O'Connor, Paul Munson, Michael Koday, Jeff Lifson, Deborah Heydenburg Fuller
Published 2016-01-01

Correction: Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation.

by Arlene I Ramsingh, Steven J Gray, Andrew Reilly, Michael Koday, Debbie Bratt, Merika Treants Koday, Paul Munson, Robert Murnane, Jeremy Smedley, Yuhui Hu, Anne Messer, Deborah Heydenburg Fuller
Published 2018-01-01

Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation.

by Arlene I Ramsingh, Steven J Gray, Andrew Reilly, Michael Koday, Debbie Bratt, Merika Treants Koday, Paul Munson, Robert Murnane, Jeremy Smedley, Yuhui Hu, Anne Messer, Deborah Heydenburg Fuller
Published 2018-01-01

Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques

by Megan A. O’Connor, Jennifer Tisoncik-Go, Thomas B. Lewis, Charlene J. Miller, Debra Bratt, Cassie R. Moats, Paul T. Edlefsen, Jeremy Smedley, Nichole R. Klatt, Michael Gale, Deborah Heydenburg Fuller
Published 2018-08-01

Efficient ex vivo expansion of conserved element vaccine-specific CD8+ T-cells from SHIV-infected, ART-suppressed nonhuman primates

by Sandra Dross, Sandra Dross, Rasika Venkataraman, Shabnum Patel, Meei-Li Huang, Catherine M. Bollard, Margherita Rosati, George N. Pavlakis, Barbara K. Felber, Katharine J. Bar, George M. Shaw, Keith R. Jerome, Keith R. Jerome, James I. Mullins, James I. Mullins, James I. Mullins, Hans-Peter Kiem, Hans-Peter Kiem, Hans-Peter Kiem, Hans-Peter Kiem, Deborah Heydenburg Fuller, Deborah Heydenburg Fuller, Christopher W. Peterson, Christopher W. Peterson
Published 2023-05-01

STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses

by Justin Theophilus Ulrich-Lewis, Justin Theophilus Ulrich-Lewis, Kevin E. Draves, Kevin E. Draves, Kelsey Roe, Kelsey Roe, Megan A. O’Connor, Edward A. Clark, Edward A. Clark, Deborah Heydenburg Fuller
Published 2022-04-01

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response.

by Merika Treants Koday, Jorgen Nelson, Aaron Chevalier, Michael Koday, Hannah Kalinoski, Lance Stewart, Lauren Carter, Travis Nieusma, Peter S Lee, Andrew B Ward, Ian A Wilson, Ashley Dagley, Donald F Smee, David Baker, Deborah Heydenburg Fuller
Published 2016-02-01

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

by David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse H Erasmus
Published 2022-02-01

Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques.

by Deborah Heydenburg Fuller, Premeela Rajakumar, Jenny W Che, Amithi Narendran, Julia Nyaundi, Heather Michael, Eric J Yager, Cristy Stagnar, Brendon Wahlberg, Rachel Taber, Joel R Haynes, Fiona C Cook, Peter Ertl, John Tite, Angela M Amedee, Michael Murphey-Corb
Published 2012-01-01

Multigenic DNA vaccine induces protective cross-reactive T cell responses against heterologous influenza virus in nonhuman primates.

by Merika T Koday, Jolie A Leonard, Paul Munson, Adriana Forero, Michael Koday, Debra L Bratt, James T Fuller, Robert Murnane, Shulin Qin, Todd A Reinhart, Karen Duus, Ilhem Messaoudi, Amy L Hartman, Kelly Stefano-Cole, Juliet Morrison, Michael G Katze, Deborah Heydenburg Fuller
Published 2017-01-01

A Gut Reaction to SIV and SHIV Infection: Lower Dysregulation of Mucosal T Cells during Acute Infection Is Associated with Greater Viral Suppression during cART

by Megan A. O’Connor, Paul V. Munson, Sandra E. Dross, Hillary C. Tunggal, Thomas B. Lewis, Jessica Osborn, Christopher W. Peterson, Meei-Li W. Huang, Cassandra Moats, Jeremy Smedley, Keith R. Jerome, Hans-Peter Kiem, Kenneth C. Bagley, James I. Mullins, Deborah Heydenburg Fuller
Published 2021-08-01

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

by David W. Hawman, Kimberly Meade-White, Chad Clancy, Jacob Archer, Troy Hinkley, Shanna S. Leventhal, Deepashri Rao, Allie Stamper, Matthew Lewis, Rebecca Rosenke, Kyle Krieger, Samantha Randall, Amit P. Khandhar, Linhue Hao, Tien-Ying Hsiang, Alexander L. Greninger, Michael Gale, Jr, Peter Berglund, Deborah Heydenburg Fuller, Kyle Rosenke, Heinz Feldmann, Jesse H. Erasmus
Published 2022-09-01

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned.

by Megan A O'Connor, David W Hawman, Kimberly Meade-White, Shanna Leventhal, Wenjun Song, Samantha Randall, Jacob Archer, Thomas B Lewis, Brieann Brown, Megan N Fredericks, Kaitlin R Sprouse, Hillary C Tunggal, Mara Maughan, Naoto Iwayama, Chul Ahrens, William Garrison, Solomon Wangari, Kathryn A Guerriero, Patrick Hanley, Jamie Lovaglio, Greg Saturday, David Veesler, Paul T Edlefsen, Amit P Khandhar, Heinz Feldmann, Deborah Heydenburg Fuller, Jesse H Erasmus
Published 2023-04-01