Alteration of protein function by a silent polymorphism linked to tRNA abundance.

by Sebastian Kirchner, Zhiwei Cai, Robert Rauscher, Nicolai Kastelic, Melanie Anding, Andreas Czech, Bertrand Kleizen, Lynda S Ostedgaard, Ineke Braakman, David N Sheppard, Zoya Ignatova
Published 2017-05-01

Experimental pharmacology in precision medicine

by Alicja Urbaniak, Kenneth E. Thummel, Ayoade N. Alade, Allan E. Rettie, Bhagwat Prasad, Amedeo De Nicolò, Jennifer H. Martin, David N. Sheppard, Michael F. Jarvis
Published 2023-12-01

Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease

by Jennifer Kelly, Miran Al-Rammahi, Kristian Daly, Paul K. Flanagan, Arun Urs, Marta C. Cohen, Gabriella di Stefano, Marcel J. C. Bijvelds, David N. Sheppard, Hugo R. de Jonge, Ursula E. Seidler, Soraya P. Shirazi-Beechey
Published 2022-04-01

In vitro platform to model the function of ionocytes in the human airway epithelium

by Marta Vilà-González, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L. Hart, Frank McCaughan, Alessandra Granata, David N. Sheppard, R. Andres Floto, Emma L. Rawlins, Pietro Cicuta, Ludovic Vallier
Published 2024-04-01

CFTR bearing variant p.Phe312del exhibits function inconsistent with phenotype and negligible response to ivacaftor

by Karen S. Raraigh, Kathleen C. Paul, Jennifer L. Goralski, Erin N. Worthington, Anna V. Faino, Stanley Sciortino, Yiting Wang, Melis A. Aksit, Hua Ling, Derek L. Osorio, Frankline M. Onchiri, Shivani U. Patel, Christian A. Merlo, Kristina Montemayor, Ronald L. Gibson, Natalie E. West, Amita Thakerar, Robert J. Bridges, David N. Sheppard, Neeraj Sharma, Garry R. Cutting
Published 2022-03-01