Soluble urokinase plasminogen activator receptor: from biomarker to active participant in atherosclerosis and cardiovascular disease

by Traci T. Goodchild, Zhen Li, David J. Lefer
Published 2022-12-01

The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure

by David J. Polhemus, John W. Calvert, Javed Butler, David J. Lefer
Published 2014-01-01

Hydrogen Sulfide Levels and Nuclear Factor‐Erythroid 2‐Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI)

by Kazi N. Islam, David J. Polhemus, Erminia Donnarumma, Luke P. Brewster, David J. Lefer
Published 2015-05-01

Hydrogen Sulfide as a Potential Therapy for Heart Failure—Past, Present, and Future

by Kyle B. LaPenna, David J. Polhemus, Jake E. Doiron, Hunter A. Hidalgo, Zhen Li, David J. Lefer
Published 2021-03-01

364 Beneficial Actions of SGLT2 Inhibition and H2S Therapy in Heart Failure with Preserved Ejection Fraction

by Jake Doiron, Zhen Li, Huijing Xia, Kyle B. Lapenna, Timothy D. Allerton, Daniel R. Kapusta, David J. Lefer
Published 2023-04-01

Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure

by Erminia Donnarumma, Shashi Bhushan, Jessica M. Bradley, Hiroyuki Otsuka, Erinn L. Donnelly, David J. Lefer, Kazi N. Islam
Published 2016-08-01

Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice.

by Yuling Chi, Jean-Francois Jasmin, Yoshinori Seki, Michael P Lisanti, Maureen J Charron, David J Lefer, Victor L Schuster
Published 2015-01-01

Combined Angiotensin Receptor–Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure

by Rishi K. Trivedi, David J. Polhemus, Zhen Li, Daniel Yoo, Hiroshi Koiwaya, Amy Scarborough, Traci T. Goodchild, David J. Lefer
Published 2018-03-01

PO-20 A HYDROGEN SULFIDE PRODRUG AUGMENTS ANGIOGENESIS IN A SWINE MODEL OF CRITICAL LIMB ISCHEMIA VIA A NITRIC OXIDE DEPENDENT MECHANISM

by Amanda M. Rushing, Amy L. Scarborough, Sarah F. Boisvert, Erminia Donnarumma, Rishi Trivedi, David J. Polhemus, David J. Lefer, Traci T. Goodchild
Published 2016-11-01

Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction

by Sumit Kar, Hamid R. Shahshahan, Tyler N. Kambis, Santosh K. Yadav, Zhen Li, David J. Lefer, Paras K. Mishra, Paras K. Mishra
Published 2019-05-01

Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

by Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer
Published 2020-05-01

Endothelial Cell Cystathionine γ‐Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury

by Huijing Xia, Zhen Li, Thomas E. Sharp, David J. Polhemus, Jean Carnal, Karl H. Moles, Ya‐Xiong Tao, John Elrod, Josef Pfeilschifter, Karl‐Friedrich Beck, David J. Lefer
Published 2020-10-01

Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics

by Axel J. Fenwick, Vivek P. Jani, D. Brian Foster, Thomas E. Sharp, Traci T. Goodchild, Kyle LaPenna, Jake E. Doiron, David J. Lefer, Joseph A. Hill, David A. Kass, Anthony Cammarato
Published 2024-01-01

Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a “2‐Hit” Murine Model

by Kyle B. LaPenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci T. Goodchild, Ravi B. Patel, Sanjiv J. Shah, David J. Lefer
Published 2023-02-01

Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction

by Jake E. Doiron, Zhen Li, Xiaoman Yu, Kyle B. LaPenna, Heather Quiriarte, Timothy D. Allerton, Kashyap Koul, Andrew Malek, Sanjiv J. Shah, Thomas E. Sharp, Traci T. Goodchild, Daniel R. Kapusta, David J. Lefer
Published 2024-02-01

Zofenopril Protects Against Myocardial Ischemia–Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability

by Erminia Donnarumma, Murtuza J. Ali, Amanda M. Rushing, Amy L. Scarborough, Jessica M. Bradley, Chelsea L. Organ, Kazi N. Islam, David J. Polhemus, Stefano Evangelista, Giuseppe Cirino, J. Stephen Jenkins, Rajan A. G. Patel, David J. Lefer, Traci T. Goodchild
Published 2016-07-01

Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop

by Amrita Ahluwalia, Mark Gladwin, Gary D. Coleman, Norman Hord, George Howard, Daniel B. Kim‐Shapiro, Martin Lajous, Filip J. Larsen, David J. Lefer, Leslie A. McClure, Bernard T. Nolan, Ryszard Pluta, Alan Schechter, Chia‐Yih Wang, Mary H. Ward, Jane L. Harman
Published 2016-07-01

Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure

by Zhen Li, BS, Chelsea L. Organ, PhD, Jianming Kang, PhD, David J. Polhemus, PhD, Rishi K. Trivedi, PhD, Thomas E. Sharp, III, PhD, Jack S. Jenkins, Ya-xiong Tao, PhD, Ming Xian, PhD, David J. Lefer, PhD
Published 2018-12-01