Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer

by Terese Geraghty, Anugraha Rajagopalan, Rabail Aslam, Alexander Pohlman, Ishwarya Venkatesh, Andrew Zloza, David Cimbaluk, David G. DeNardo, David G. DeNardo, David G. DeNardo, Vineet Gupta, Vineet Gupta
Published 2020-05-01

Rethinking immune checkpoint blockade: ‘Beyond the T cell’

by Xiuting Liu, David G DeNardo, Graham D Hogg
Published 2021-01-01

GB1275, a first-in-class CD11b modulator: rationale for immunotherapeutic combinations in solid tumors

by David G DeNardo, Johanna Bendell, Lei Zhou, Jakob Dupont, Anna Galkin
Published 2021-08-01

Tumor Microenvironment as a Regulator of Radiation Therapy: New Insights into Stromal-Mediated Radioresistance

by Varintra E. Krisnawan, Jennifer A. Stanley, Julie K. Schwarz, David G. DeNardo
Published 2020-10-01

Combination TIGIT/PD-1 blockade enhances the efficacy of neoantigen vaccines in a model of pancreatic cancer

by Hui Peng, Lijin Li, Chong Zuo, Michael Y. Chen, Xiuli Zhang, Nancy B. Myers, Graham D. Hogg, David G. DeNardo, David G. DeNardo, S. Peter Goedegebuure, S. Peter Goedegebuure, William G. Hawkins, William G. Hawkins, William E. Gillanders, William E. Gillanders
Published 2022-12-01

#46. cAMP-mediated acid signaling regulates tumor-myeloid-bone cell crosstalk in the bone-tumor microenvironment

by Kaylee O'Donnell, Xinming Su, Yalin Xu, Kristin A. Kwakwa, Deborah J. Veis, David G. DeNardo, Gregory M. Lanza, Katherine N. Weilbaecher
Published 2024-04-01

Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

by Julie G Grossman, Timothy M Nywening, Brian A Belt, Roheena Z Panni, Bradley A Krasnick, David G DeNardo, William G Hawkins, S Peter Goedegebuure, David C Linehan, Ryan C Fields
Published 2018-09-01

Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma

by Vikram S. Pothuri, Graham D. Hogg, Leah Conant, Nicholas Borcherding, C. Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G. Hawkins, Venu G. Pillarisetty, David G. DeNardo, Ryan C. Fields
Published 2024-12-01

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis

by Callie A.S. Corsa, Audrey Brenot, Whitney R. Grither, Samantha Van Hove, Andrew J. Loza, Kun Zhang, Suzanne M. Ponik, Yuming Liu, David G. DeNardo, Kevin W. Eliceiri, Patricia J. Keely, Gregory D. Longmore
Published 2016-06-01

Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

by Roman V. Uzhachenko, Vijaya Bharti, Zhufeng Ouyang, Ashlyn Blevins, Stacey Mont, Nabil Saleh, Hunter A. Lawrence, Chengli Shen, Sheau-Chiann Chen, Gregory D. Ayers, David G. DeNardo, Carlos Arteaga, Ann Richmond, Anna E. Vilgelm
Published 2021-04-01

Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma

by Arja Ray, Mackenzie K. Callaway, Nelson J. Rodríguez-Merced, Alexandra L. Crampton, Marjorie Carlson, Kenneth B. Emme, Ethan A. Ensminger, Alexander A. Kinne, Jonathan H. Schrope, Haley R. Rasmussen, Hong Jiang, David G. DeNardo, David K. Wood, Paolo P. Provenzano
Published 2022-02-01

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

by Megan K. Ruhland, Andrew J. Loza, Aude-Helene Capietto, Xianmin Luo, Brett L. Knolhoff, Kevin C. Flanagan, Brian A. Belt, Elise Alspach, Kathleen Leahy, Jingqin Luo, Andras Schaffer, John R. Edwards, Gregory Longmore, Roberta Faccio, David G. DeNardo, Sheila A. Stewart
Published 2016-06-01

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

by Melissa A. Meyer, John M. Baer, Brett L. Knolhoff, Timothy M. Nywening, Roheena Z. Panni, Xinming Su, Katherine N. Weilbaecher, William G. Hawkins, Cynthia Ma, Ryan C. Fields, David C. Linehan, Grant A. Challen, Roberta Faccio, Rebecca L. Aft, David G. DeNardo
Published 2018-03-01

Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response

by Anthony Z. Wang, Jay A. Bowman-Kirigin, Rupen Desai, Liang-I Kang, Pujan R. Patel, Bhuvic Patel, Saad M. Khan, Diane Bender, M. Caleb Marlin, Jingxian Liu, Joshua W. Osbun, Eric C. Leuthardt, Michael R. Chicoine, Ralph G. Dacey, Gregory J. Zipfel, Albert H. Kim, David G. DeNardo, Allegra A. Petti, Gavin P. Dunn
Published 2022-05-01

Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer

by Ashenafi Bulle, Peng Liu, Kuljeet Seehra, Sapana Bansod, Yali Chen, Kiran Zahra, Vikas Somani, Iftikhar Ali Khawar, Hung-Po Chen, Paarth B. Dodhiawala, Lin Li, Yutong Geng, Chia-Kuei Mo, Jay Mahsl, Li Ding, Ramaswamy Govindan, Sherri Davies, Jacqueline Mudd, William G. Hawkins, Ryan C. Fields, David G. DeNardo, Deborah Knoerzer, Jason M. Held, Patrick M. Grierson, Andrea Wang-Gillam, Marianna B. Ruzinova, Kian-Huat Lim
Published 2024-03-01

Targeting stromal p38MAPKalpha triggers innate-adaptive anti-tumor immunity and sensitizes metastatic breast cancer to immunotherapy

by Douglas V. Faget, Xianmin Luo, Matthew J. Inkman, Qihao Ren, Xinming Su, Kai Ding, Michael R. Waters, Ganesh Kumar Raut, Gaurav Pandey, Paarth B. Dodhiawala, Renata Ramalho-Oliveira, Jiayu Ye, Thomas Cole, Bhavna Murali, Alexander Zheleznyak, Monica Shokeen, Kurt R. Weiss, Joseph B. Monahan, Carl J. DeSelm, Adrian V. Lee, Steffi Oesterreich, Katherine N. Weilbaecher, Jin Zhang, David G. DeNardo, Sheila A. Stewart
Published 2024-04-01

Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

by Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M. Coussens, Daniel D. De Carvalho, David G. DeNardo, Jérôme Galon, Howard L. Kaufman, Tomas Kirchhoff, Michael T. Lotze, Jason J. Luke, Andy J. Minn, Katerina Politi, Leonard D. Shultz, Richard Simon, Vésteinn Thórsson, Joanne B. Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M. Barnes, Valentin Barsan, Praveen K. Bommareddy, Adrian Bot, Sarah E. Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S. Ho, Heather M. McGee, Anne Monette, Joseph F. Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F. Sweis, Sara Valpione, Roberta Zappasodi, Lisa H. Butterfield, Mary L. Disis, Bernard A. Fox, Alessandra Cesano, Francesco M. Marincola, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups
Published 2019-05-01

Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

by Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M. Coussens, Daniel D. De Carvalho, David G. DeNardo, Jérôme Galon, Howard L. Kaufman, Tomas Kirchhoff, Michael T. Lotze, Jason J. Luke, Andy J. Minn, Katerina Politi, Leonard D. Shultz, Richard Simon, Vésteinn Thórsson, Joanne B. Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M. Barnes, Valentin Barsan, Praveen K. Bommareddy, Adrian Bot, Sarah E. Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S. Ho, Heather M. McGee, Anne Monette, Joseph F. Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F. Sweis, Sara Valpione, Roberta Zappasodi, Lisa H. Butterfield, Mary L. Disis, Bernard A. Fox, Alessandra Cesano, Francesco M. Marincola, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups
Published 2019-07-01