RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.

by Dharmalingam Subramaniam, Satish Ramalingam, David C Linehan, Brian K Dieckgraefe, Russell G Postier, Courtney W Houchen, Roy A Jensen, Shrikant Anant
Published 2011-02-01

Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

by Julie G Grossman, Timothy M Nywening, Brian A Belt, Roheena Z Panni, Bradley A Krasnick, David G DeNardo, William G Hawkins, S Peter Goedegebuure, David C Linehan, Ryan C Fields
Published 2018-09-01

Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model

by Shuyang S. Qin, Booyeon J. Han, Alyssa Williams, Katherine M. Jackson, Rachel Jewell, Alexander C. Chacon, Edith M. Lord, David C. Linehan, Minsoo Kim, Alexandre Reuben, Scott A. Gerber, Peter A. Prieto
Published 2021-05-01

CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models

by Jian Ye, Brian A Belt, David C Linehan, Tara G Vrooman, Carl J Johnston, Edith M Lord, Scott A Gerber, Nicholas W Gavras, David C Keeley, Angela L Hughson, Gary Hannon, Maggie L Lesch, Jim Eyles
Published 2023-05-01

Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer

by Jian Ye, Brian A Belt, Booyeon J Han, David C Linehan, Shuyang S Qin, Bradley N Mills, Jesse Garrett-Larsen, Joseph D Murphy, Taylor P Uccello, Tara G Vrooman, Carl J Johnston, Edith M Lord, Scott A Gerber
Published 2022-07-01

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

by Melissa A. Meyer, John M. Baer, Brett L. Knolhoff, Timothy M. Nywening, Roheena Z. Panni, Xinming Su, Katherine N. Weilbaecher, William G. Hawkins, Cynthia Ma, Ryan C. Fields, David C. Linehan, Grant A. Challen, Roberta Faccio, Rebecca L. Aft, David G. DeNardo
Published 2018-03-01

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment

by Bradley N. Mills, Kelli A. Connolly, Jian Ye, Joseph D. Murphy, Taylor P. Uccello, Booyeon J. Han, Tony Zhao, Michael G. Drage, Aditi Murthy, Haoming Qiu, Ankit Patel, Nathania M. Figueroa, Carl J. Johnston, Peter A. Prieto, Nejat K. Egilmez, Brian A. Belt, Edith M. Lord, David C. Linehan, Scott A. Gerber
Published 2019-10-01

New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy

by Taylor P. Uccello, Maggie L. Lesch, Sarah A. Kintzel, Lauren B. Gradzewicz, Lillia Lamrous, Shawn P. Murphy, Fergal J. Fleming, Bradley N. Mills, Joseph D. Murphy, Angela Hughson, Gary Hannon, Jesse Garrett-Larsen, Haoming Qiu, Michael G. Drage, Jian Ye, Nicholas W. Gavras, David C. Keeley, Tanzy M. T. Love, Elizabeth A. Repasky, Edith M. Lord, David C. Linehan, Scott A. Gerber
Published 2023-07-01

Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy

by Taylor P. Uccello, MS, Sarah A. Kintzel, BS, Bradley N. Mills, PhD, Joseph D. Murphy, MS, Jesse Garrett-Larsen, BS, Nicholas G. Battaglia, PhD, Carlos J. Rodriguez, BS, Michael G. Drage, MD, Jian Ye, PhD, Tanzy M.T. Love, PhD, Carl J. Johnston, PhD, Elizabeth A. Repasky, PhD, Haoming Qiu, MD, David C. Linehan, MD, Edith M. Lord, PhD, Scott A. Gerber, PhD
Published 2022-03-01

Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1

by Negar Khazan, Emily R. Quarato, Niloy A. Singh, Cameron W. A. Snyder, Taylor Moore, John P. Miller, Masato Yasui, Yuki Teramoto, Takuro Goto, Sabeeha Reshi, Jennifer Hong, Naixin Zhang, Diya Pandey, Priyanka Srivastava, Alexandra Morell, Hiroki Kawano, Yuko Kawano, Thomas Conley, Deepak M. Sahasrabudhe, Naohiro Yano, Hiroshi Miyamoto, Omar Aljitawi, Jane Liesveld, Michael W. Becker, Laura M. Calvi, Alexander S. Zhovmer, Erdem D. Tabdanov, Nikolay V. Dokholyan, David C. Linehan, Jeanne N. Hansen, Scott A. Gerber, Ashoke Sharon, Manoj K. Khera, Peter W. Jurutka, Natacha Rochel, Kyu Kwang Kim, Rachael B. Rowswell-Turner, Rakesh K. Singh, Richard G. Moore
Published 2023-06-01