A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

by David V Liu, Nicole J Yang, K Dane Wittrup
Published 2014-01-01

876 Intratumoral administration and local retention of IL-2/IL-12 fusion proteins drive a potent systemic anti-tumor immune response

by Patrick Baeuerle, Jennifer Michaelson, Dane Wittrup, Mehta Naveen, Bochong Li
Published 2021-11-01

183 Overcoming immunotherapy resistance in T cell-inflamed lung cancer

by Brendan Horton, Duncan Morgan, Noor Momin, Vidit Bhandarkar, Dane Wittrup, Chris Love
Published 2020-11-01

947 The activation states of tumor-resident type 2 dendritic cells impact the strength of ovarian cancer immune responses

by Stefani Spranger, Fiona Chatterjee, Emi A Lutz, K Dane Wittrup, Vincent Butty
Published 2023-11-01

Order of administration of combination cytokine therapies can decouple toxicity from efficacy in syngeneic mouse tumor models

by Adrienne Rothschilds, Alice Tzeng, Naveen K. Mehta, Kelly D. Moynihan, Darrell J. Irvine, K. Dane Wittrup
Published 2019-05-01

Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice.

by Byong H Kang, Noor Momin, Kelly D Moynihan, Murillo Silva, Yingzhong Li, Darrell J Irvine, K Dane Wittrup
Published 2021-01-01

1011 The signal strength of signal 2 and 3 during T cell priming affect the functional fate of an anti-tumor T cell response

by Stefani Spranger, Duncan Morgan, Vidit Bhandarkar, Teresa Dinter, Lorelai Pop, Emi A Lutz, K Dane Wittrup, J Christopher Love
Published 2023-11-01

High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming

by Guangan Hu, Yang Su, Byong Ha Kang, Zhongqi Fan, Ting Dong, Douglas R. Brown, Jaime Cheah, Karl Dane Wittrup, Jianzhu Chen
Published 2021-02-01

1093 CLN-617 combines IL-2 and IL-12 in a single molecule to optimally balance safety and efficacy upon intratumoral injection

by Naveen K Mehta, Patrick A Baeuerle, Jennifer S Michaelson, Laura Liu, K Dane Wittrup, Kristan A Meetze, Irina M Shapiro, Kavya Rakhra
Published 2023-11-01

Tumor-localized catalases can fail to alter tumor growth and transcriptional profiles in subcutaneous syngeneic mouse tumor models

by Allison Sheen, Yash Agarwal, Keith M. Cheah, Sarah C. Cowles, Jordan A. Stinson, Joseph R. Palmeri, Hadley D. Sikes, K. Dane Wittrup
Published 2023-08-01

An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

by Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup
Published 2022-12-01

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

by Alessandro Angelini, Yoshishige Miyabe, Daniel Newsted, Byron H. Kwan, Chie Miyabe, Ryan L. Kelly, Misha N. Jamy, Andrew D. Luster, K. Dane Wittrup
Published 2018-04-01

An engineered protein antagonist of K-Ras/B-Raf interaction

by Monique J. Kauke, Michael W. Traxlmayr, Jillian A. Parker, Jonathan D. Kiefer, Ryan Knihtila, John McGee, Greg Verdine, Carla Mattos, K. Dane Wittrup
Published 2017-07-01

Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma

by Didier Dréau, Laura Jeffords Moore, Mike Wu, Lopa Das Roy, Lloye Dillion, Travis Porter, Rahul Puri, Noor Momin, K. Dane Wittrup, Pinku Mukherjee, Pinku Mukherjee
Published 2019-04-01

1224 Tregs constrain CD8 + T cell priming required for curative intratumorally anchored anti-4–1BB immunotherapy

by Emi A Lutz, K Dane Wittrup, Joseph R Palmeri, Brianna M Lax, Josh M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, William Pinney, Bryan D Bryson
Published 2023-11-01

1094 Collagen-anchored IL-2 and IL-12 cytokines potentiate anti-tumor immunity in advanced canine cancers

by Noor Momin, K Dane Wittrup, Jordan A Stinson, Matheus Moreno M Passos Barbosa, Allison Sheen, Jordan Hampel, Elizabeth Fink, Rebecca Kamerer, Jonathan Samuelson, Rebecca Bernstein, Timothy Fan
Published 2023-11-01

CD8+ T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs

by Joseph R. Palmeri, Brianna M. Lax, Joshua M. Peters, Lauren Duhamel, Jordan A. Stinson, Luciano Santollani, Emi A. Lutz, William Pinney, Bryan D. Bryson, K. Dane Wittrup
Published 2024-03-01

Maximizing response to intratumoral immunotherapy in mice by tuning local retention

by Noor Momin, Joseph R. Palmeri, Emi A. Lutz, Noor Jailkhani, Howard Mak, Anthony Tabet, Magnolia M. Chinn, Byong H. Kang, Virginia Spanoudaki, Richard O. Hynes, K. Dane Wittrup
Published 2022-01-01

Identification of Highly Cross-Reactive Mimotopes for a Public T Cell Response in Murine Melanoma

by Beth E. Grace, Beth E. Grace, Coralie M. Backlund, Coralie M. Backlund, Duncan M. Morgan, Duncan M. Morgan, Byong H. Kang, Byong H. Kang, Nishant K. Singh, Nishant K. Singh, Nishant K. Singh, Brooke D. Huisman, Brooke D. Huisman, C. Garrett Rappazzo, C. Garrett Rappazzo, Kelly D. Moynihan, Kelly D. Moynihan, Laura Maiorino, Laura Maiorino, Connor S. Dobson, Connor S. Dobson, Taeyoon Kyung, Taeyoon Kyung, Khloe S. Gordon, Khloe S. Gordon, Patrick V. Holec, Patrick V. Holec, Overbeck C. Takou Mbah, Daniel Garafola, Shengwei Wu, J. Christopher Love, J. Christopher Love, J. Christopher Love, K. Dane Wittrup, K. Dane Wittrup, K. Dane Wittrup, Darrell J. Irvine, Darrell J. Irvine, Darrell J. Irvine, Michael E. Birnbaum, Michael E. Birnbaum, Michael E. Birnbaum
Published 2022-06-01

Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2

by Brendan L. Horton, Alicia D. D’Souza, Maria Zagorulya, Chloe V. McCreery, Gita C. Abhiraman, Lora Picton, Allison Sheen, Yash Agarwal, Noor Momin, K. Dane Wittrup, Forest M. White, K. Christopher Garcia, Stefani Spranger
Published 2023-10-01