Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors

by Kerry A. Whalen, Kavya Rakhra, Naveen K. Mehta, Alexander Steinle, Jennifer S. Michaelson, Patrick A. Baeuerle
Published 2023-12-01

1024 CLN-978, a novel CD19/CD3/HSA T cell engager with extended serum half-life, is effective against lymphoma cells expressing very low levels of CD19

by Agapitos Patakas, Naveen K Mehta, Patrick A Baeuerle, Jennifer S Michaelson, Kristan A Meetze, Hannah M Findlay, Timothy B London
Published 2023-11-01

CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression

by Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London
Published 2023-08-01

1093 CLN-617 combines IL-2 and IL-12 in a single molecule to optimally balance safety and efficacy upon intratumoral injection

by Naveen K Mehta, Patrick A Baeuerle, Jennifer S Michaelson, Laura Liu, K Dane Wittrup, Kristan A Meetze, Irina M Shapiro, Kavya Rakhra
Published 2023-11-01

1171 CLN-418, a clinical-stage B7H4 x 4–1BB bispecific antibody with potential to treat patients with a wide range of solid tumors

by Yun He, Ella Ioffe, Bing Huang, Naveen K Mehta, Patrick A Baeuerle, Jennifer S Michaelson, Kristan A Meetze, Irina M Shapiro, Hanna Dobrowolska
Published 2023-11-01

771 A phase 1 study to assess safety, efficacy, pharmacokinetics, and pharmacodynamics of intratumoral CLN-617 (IL2/IL12 fusion protein) combined with pembrolizumab in patients wit...

by Evan Hall, Adi Diab, Sajeve Thomas, Randy Sweis, Anthony El-Khoueiry, Naveen K Mehta, Jennifer S Michaelson, Laura Liu, Reham Abdel-Wahab, Jeffrey A Jones, Kaida Wu, Benjamin S Maciejewski
Published 2023-11-01

194 Characterization of the pharmacodynamic activity of CLN-619, an anti-MICA/B monoclonal antibody, in patients from an ongoing Phase 1 trial

by Victor Moreno, Ignacio Melero, Michael Millward, Tracy Liu, Rafał Stec, Erika Hamilton, Ana Maria Arance, Jennifer S Michaelson, Laura Liu, Alexander I Spira, Judy S Wang, Irina M Shapiro, Kerry A Whalen, Jeffrey A Jones
Published 2023-11-01

A novel IgG-based FLT3xCD3 bispecific antibody for the treatment of AML and B-ALL

by Melanie Märklin, Gundram Jung, Jonas S Heitmann, Joseph Kauer, Helmut R Salih, Stefanie Mueller, Bochong Li, Latifa Zekri, Naveen K Mehta, Martin Pfluegler, Kristan Meetze, Isabelle Sindel, Fabian Vogt, Lukas Osburg, Hans-Jörg Bühring, Sebastian Hörner, Patrick A Baeuerle, Jennifer S Michaelson
Published 2022-03-01