Enhanced activation of memory, but not naïve, B cells in chronic hepatitis C virus-infected patients with cryoglobulinemia and advanced liver fibrosis.

by Deanna M Santer, Mang M Ma, Darren Hockman, Abdolamir Landi, D Lorne J Tyrrell, Michael Houghton
Published 2013-01-01

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19

by Maral Aminpour, Williams Ernesto Miranda Delgado, Soren Wacker, Sergey Noskov, Michael Houghton, D. Lorne J. Tyrrell, Jack A. Tuszynski
Published 2021-10-01

Therapeutic efficacy of human hepatocyte transplantation in a SCID/uPA mouse model with inducible liver disease.

by Donna N Douglas, Toshiyasu Kawahara, Banu Sis, David Bond, Karl P Fischer, D Lorne J Tyrrell, Jamie T Lewis, Norman M Kneteman
Published 2010-02-01

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites.

by Christopher J Neufeldt, Michael A Joyce, Nicholas Van Buuren, Aviad Levin, Karla Kirkegaard, Michael Gale, D Lorne J Tyrrell, Richard W Wozniak
Published 2016-02-01

Hepatitis C virus-induced cytoplasmic organelles use the nuclear transport machinery to establish an environment conducive to virus replication.

by Christopher J Neufeldt, Michael A Joyce, Aviad Levin, Rineke H Steenbergen, Daniel Pang, Justin Shields, D Lorne J Tyrrell, Richard W Wozniak
Published 2013-10-01

Functional characterization of nuclear localization and export signals in hepatitis C virus proteins and their role in the membranous web.

by Aviad Levin, Christopher J Neufeldt, Daniel Pang, Kristen Wilson, Darci Loewen-Dobler, Michael A Joyce, Richard W Wozniak, D Lorne J Tyrrell
Published 2014-01-01

Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity

by Deanna M. Santer, Daniel Li, Yanal Ghosheh, Muhammad Atif Zahoor, Dhanvi Prajapati, Bettina E. Hansen, D. Lorne J. Tyrrell, Jordan J. Feld, Adam J. Gehring
Published 2022-11-01

Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.

by Yutaka Takebe, Carrie J Saucedo, Garry Lund, Rie Uenishi, Saiki Hase, Takayo Tsuchiura, Norman Kneteman, Koreen Ramessar, D Lorne J Tyrrell, Masayuki Shirakura, Takaji Wakita, James B McMahon, Barry R O'Keefe
Published 2013-01-01

IL-28B is a key regulator of B- and T-cell vaccine responses against influenza.

by Adrian Egli, Deanna M Santer, Daire O'Shea, Khaled Barakat, Mohammedyaseen Syedbasha, Madeleine Vollmer, Aliyah Baluch, Rakesh Bhat, Jody Groenendyk, Michael A Joyce, Luiz F Lisboa, Brad S Thomas, Manuel Battegay, Nina Khanna, Thomas Mueller, D Lorne J Tyrrell, Michael Houghton, Atul Humar, Deepali Kumar
Published 2014-12-01