A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

by Xavier Taylor, Pablo Cisternas, Yanwen You, Yingjian You, Shunian Xiang, Yamil Marambio, Jie Zhang, Ruben Vidal, Cristian A. Lasagna-Reeves
Published 2020-07-01

Activated endothelial cells induce a distinct type of astrocytic reactivity

by Xavier Taylor, Pablo Cisternas, Nur Jury, Pablo Martinez, Xiaoqing Huang, Yanwen You, Javier Redding-Ochoa, Ruben Vidal, Jie Zhang, Juan Troncoso, Cristian A. Lasagna-Reeves
Published 2022-03-01

TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo

by Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L. Oblak, Cristian A. Lasagna-Reeves
Published 2023-06-01

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

by Marcos J. Guerrero-Muñoz, Diana L. Castillo-Carranza, Shashirekha Krishnamurthy, Adriana A. Paulucci-Holthauzen, Urmi Sengupta, Cristian A. Lasagna-Reeves, Yembur Ahmad, George R. Jackson, Rakez Kayed
Published 2014-11-01

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy

by Yingjian You, Abigail Perkins, Pablo Cisternas, Braulio Muñoz, Xavier Taylor, Yanwen You, Holly J. Garringer, Adrian L. Oblak, Brady K. Atwood, Ruben Vidal, Cristian A. Lasagna-Reeves
Published 2019-02-01

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes

by Cristian A Lasagna-Reeves, Maxime WC Rousseaux, Marcos J Guerrero-Munoz, Luis Vilanova-Velez, Jeehye Park, Lauren See, Paymaan Jafar-Nejad, Ronald Richman, Harry T Orr, Rakez Kayed, Huda Y Zoghbi
Published 2015-12-01

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

by Shweta S. Puntambekar, Miguel Moutinho, Peter Bor-Chian Lin, Vaishnavi Jadhav, Danika Tumbleson-Brink, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian Oblak, Cristian A. Lasagna-Reeves, Gary E. Landreth, Bruce T. Lamb
Published 2022-06-01

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

by Cristian A Lasagna-Reeves, Maxime WC Rousseaux, Marcos J Guerrero-Muñoz, Jeehye Park, Paymaan Jafar-Nejad, Ronald Richman, Nan Lu, Urmi Sengupta, Alexandra Litvinchuk, Harry T Orr, Rakez Kayed, Huda Y Zoghbi
Published 2015-05-01

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

by Shane M. Bemiller, Tyler J. McCray, Kevin Allan, Shane V. Formica, Guixiang Xu, Gina Wilson, Olga N. Kokiko-Cochran, Samuel D. Crish, Cristian A. Lasagna-Reeves, Richard M. Ransohoff, Gary E. Landreth, Bruce T. Lamb
Published 2017-10-01

TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

by Miguel Moutinho, Israel Coronel, Andy P. Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K. Atwood, Shweta S. Puntambekar, Daniel C. Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A. Lasagna-Reeves, Bruce T. Lamb, Stephanie J. Bissel, Kwangsik Nho, Gary E. Landreth
Published 2023-02-01

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

by Maxime WC Rousseaux, Maria de Haro, Cristian A Lasagna-Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar-Nejad, Ismael Al-Ramahi, Ajay Sharma, Lauren See, Nan Lu, Luis Vilanova-Velez, Tiemo J Klisch, Thomas F Westbrook, Juan C Troncoso, Juan Botas, Huda Y Zoghbi
Published 2016-10-01