Chipping away at diagnostics for neurodegenerative diseases

by Clemens R. Scherzer
Published 2009-08-01

A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain

by Rachit Bakshi, Shuchi Mittal, Zhixiang Liao, Clemens R. Scherzer
Published 2016-01-01

Network analysis identifies SOD2 mRNA as a potential biomarker for Parkinson's disease.

by Jose A Santiago, Clemens R Scherzer, Judith A Potashkin
Published 2014-01-01

Understanding the effect of smoking and drinking behavior on Parkinson's disease risk: a Mendelian randomization study

by Carmen Domínguez-Baleón, Jue-Sheng Ong, Clemens R. Scherzer, Miguel E. Rentería, Xianjun Dong
Published 2021-07-01

Potential two‐step proteomic signature for Parkinson's disease: Pilot analysis in the Harvard Biomarkers Study

by Sid E. O'Bryant, Melissa Edwards, Fan Zhang, Leigh A. Johnson, James Hall, Yuliya Kuras, Clemens R. Scherzer
Published 2019-12-01

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

by Luis Fonseca-Ornelas, Jonathan M. S. Stricker, Stephanie Soriano-Cruz, Beatrice Weykopf, Ulf Dettmer, Christina R. Muratore, Clemens R. Scherzer, Dennis J. Selkoe
Published 2022-09-01

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

by Vikram Khurana, Ilan Elson-Schwab, Tudor A Fulga, Katherine A Sharp, Carin A Loewen, Erin Mulkearns, Jaana Tyynelä, Clemens R Scherzer, Mel B Feany
Published 2010-07-01

Cellular Distribution of NMDA Glutamate Receptor Subunit mRNAs in the Human Cerebellum

by Clemens R. Scherzer, G.Bernhard Landwehrmeyer, Julie A. Kerner, David G. Standaert, Zane R. Hollingsworth, Lorrie P. Daggett, Gönül Veliçelebi, John B. Penney, Jr., Anne B. Young
Published 1997-01-01

Plasma-borne indicators of inflammasome activity in Parkinson’s disease patients

by Faith L. Anderson, Katharine M. von Herrmann, Angeline S. Andrew, Yuliya I. Kuras, Alison L. Young, Clemens R. Scherzer, William F. Hickey, Stephen L. Lee, Matthew C. Havrda
Published 2021-01-01

DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood

by Adrienne Henderson-Smith, Kathleen M. Fisch, Jianping Hua, Ganqiang Liu, Eugenia Ricciardelli, Kristen Jepsen, Mathew Huentelman, Gabriel Stalberg, Steven D. Edland, Clemens R. Scherzer, Travis Dunckley, Paula Desplats
Published 2019-04-01

Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease

by Xianjun Dong, Yunfei Bai, Zhixiang Liao, David Gritsch, Xiaoli Liu, Tao Wang, Rebeca Borges-Monroy, Alyssa Ehrlich, Geidy E. Serrano, Mel B. Feany, Thomas G. Beach, Clemens R. Scherzer
Published 2023-09-01

Differential blood DNA methylation across Lewy body dementias

by Chanond A. Nasamran, Anubhav Nikunj Singh Sachan, Jennifer Mott, Yuliya I. Kuras, Clemens R. Scherzer, Harvard Biomarkers Study, Eugenia Ricciardelli, Kristen Jepsen, Steven D. Edland, Kathleen M. Fisch, Paula Desplats
Published 2021-01-01

Disease progression strikingly differs in research and real-world Parkinson’s populations

by Brett K. Beaulieu-Jones, Francesca Frau, Sylvie Bozzi, Karen J. Chandross, M. Judith Peterschmitt, Caroline Cohen, Catherine Coulovrat, Dinesh Kumar, Mark J. Kruger, Scott L. Lipnick, Lane Fitzsimmons, Isaac S. Kohane, Clemens R. Scherzer
Published 2024-03-01

Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease

by Pu-Ting Xu, Yi-Ju Li, Xue-Jun Qin, Clemens R. Scherzer, Hong Xu, Donald E. Schmechel, Christine M. Hulette, John Ervin, Steven R. Gullans, Jonathan Haines, Margaret A. Pericak-Vance, John R. Gilbert
Published 2006-02-01

Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson’s disease enrolled in PPMI

by Young Eun Huh, Hyejung Park, Ming Sum Ruby Chiang, Idil Tuncali, Ganqiang Liu, Joseph J. Locascio, Julia Shirvan, Samantha J. Hutten, Melissa S. Rotunno, Catherine Viel, Lamya S. Shihabuddin, Bing Wang, Sergio Pablo Sardi, Clemens R. Scherzer
Published 2021-11-01

Australian Parkinson’s Genetics Study (APGS): pilot (n=1532)

by Jacob Gratten, Clemens R Scherzer, Sarah E Medland, Richard Parker, Simone Cross, Nicholas G Martin, Penelope A Lind, George D Mellick, Peter M Visscher, Danuta Z Loesch, Svetlana Bivol, Aoibhe Mulcahy, Philip E Mosley, Peter C Poortvliet, Adrian I Campos, Brittany L Mitchell, Luis M Garcia-Marin, Mary Ferguson, Miguel E Rentería
Published 2022-02-01

Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment

by Pia Kivisäkk, Becky C. Carlyle, Becky C. Carlyle, Thadryan Sweeney, Bianca A. Trombetta, Kathryn LaCasse, Leena El-Mufti, Idil Tuncali, Lori B. Chibnik, Lori B. Chibnik, Sudeshna Das, Clemens R. Scherzer, Keith A. Johnson, Bradford C. Dickerson, Teresa Gomez-Isla, Deborah Blacker, Derek H. Oakley, Matthew P. Frosch, Bradley T. Hyman, Anahit Aghvanyan, Pradeepthi Bathala, Christopher Campbell, George Sigal, Martin Stengelin, Steven E. Arnold
Published 2023-03-01

Network Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Disease

by Santiago, Jose A., Scherzer, Clemens R., Potashkin, Judith A.
Published 2014

A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain

by Bakshi, Rachit, Mittal, Shuchi, Liao, Zhixiang, Scherzer, Clemens R.
Published 2016

Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

by Khurana, Vikram, Elson-Schwab, Ilan, Fulga, Tudor Alexandru, Sharp, Katherine A., Loewen, Carin A., Mulkearns, Erin, Tyynelä, Jaana, Scherzer, Clemens, Feany, Mel B.
Published 2012