A multiscale spatial modeling framework for the germinal center response

by Derek P. Mu, Christopher D. Scharer, Norbert E. Kaminski, Qiang Zhang
Published 2024-05-01

Progressive Upregulation of Oxidative Metabolism Facilitates Plasmablast Differentiation to a T-Independent Antigen

by Madeline J. Price, Dillon G. Patterson, Christopher D. Scharer, Jeremy M. Boss
Published 2018-06-01

Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment.

by Christopher M Collins, Christopher D Scharer, Thomas J Murphy, Jeremy M Boss, Samuel H Speck
Published 2020-04-01

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs

by Christopher D. Scharer, Benjamin G. Barwick, Muyao Guo, Alexander P. R. Bally, Jeremy M. Boss
Published 2018-04-01

Antibody-secreting cell destiny emerges during the initial stages of B-cell activation

by Christopher D. Scharer, Dillon G. Patterson, Tian Mi, Madeline J. Price, Sakeenah L. Hicks, Jeremy M. Boss
Published 2020-08-01

CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation

by Zhihong Zuo, Anna K. Kania, Dillon G. Patterson, Sakeenah L. Hicks, Jeffrey Maurer, Mansi Gupta, Jeremy M. Boss, Christopher D. Scharer
Published 2023-06-01

Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential

by James R. Rose, Bagdeser Akdogan-Ozdilek, Andrew R. Rahmberg, Michael D. Powell, Sakeenah L. Hicks, Christopher D. Scharer, Jeremy M. Boss
Published 2023-04-01

Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway

by Rheinallt M. Jones, Chirayu Desai, Trevor M. Darby, Liping Luo, Alexandra A. Wolfarth, Christopher D. Scharer, Courtney S. Ardita, April R. Reedy, Erin S. Keebaugh, Andrew S. Neish
Published 2015-08-01

B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

by Benjamin G. Barwick, Christopher D. Scharer, Ryan J. Martinez, Madeline J. Price, Alexander N. Wein, Robert R. Haines, Alexander P. R. Bally, Jacob E. Kohlmeier, Jeremy M. Boss
Published 2018-05-01

Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs

by Miyoung Lee, Delaney K. Geitgey, Jamie A. G. Hamilton, Jeremy M. Boss, Christopher D. Scharer, Jennifer M. Spangle, Jennifer M. Spangle, Karmella A. Haynes, Curtis J. Henry, Curtis J. Henry
Published 2022-08-01

Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence.

by Omer Gokcumen, Qihui Zhu, Lubbertus C F Mulder, Rebecca C Iskow, Christian Austermann, Christopher D Scharer, Towfique Raj, Jeremy M Boss, Shamil Sunyaev, Alkes Price, Barbara Stranger, Viviana Simon, Charles Lee
Published 2013-04-01

Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia

by Miyoung Lee, Jamie A. G. Hamilton, Ganesh R. Talekar, Anthony J. Ross, Langston Michael, Manali Rupji, Bhakti Dwivedi, Sunil S. Raikar, Jeremy Boss, Christopher D. Scharer, Douglas K. Graham, Deborah DeRyckere, Christopher C. Porter, Curtis J. Henry
Published 2022-03-01

Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE responses to helminth infection

by Miranda L. Curtiss, Miranda L. Curtiss, Alexander F. Rosenberg, Alexander F. Rosenberg, Christopher D. Scharer, Betty Mousseau, Natalia A. Ballesteros Benavides, Natalia A. Ballesteros Benavides, John E. Bradley, Beatriz León, Chad Steele, Troy D. Randall, Frances E. Lund
Published 2023-07-01

Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes

by Martin A. Rivas, Ceyda Durmaz, Andreas Kloetgen, Cristopher R. Chin, Cristopher R. Chin, Zhengming Chen, Bhavneet Bhinder, Bhavneet Bhinder, Bhavneet Bhinder, Amnon Koren, Aaron D. Viny, Aaron D. Viny, Christopher D. Scharer, Jeremy M. Boss, Olivier Elemento, Olivier Elemento, Olivier Elemento, Christopher E. Mason, Christopher E. Mason, Christopher E. Mason, Christopher E. Mason, Ari M. Melnick
Published 2021-09-01

Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus

by Weirong Chen, So-Hee Hong, Scott A. Jenks, Fabliha A. Anam, Christopher M. Tipton, Matthew C. Woodruff, Jennifer R. Hom, Kevin S. Cashman, Caterina Elisa Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D. Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C. Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, F. Eun-Hyung Lee, Ignacio Sanz
Published 2024-03-01

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

by Esther Zumaquero, Sara L Stone, Christopher D Scharer, Scott A Jenks, Anoma Nellore, Betty Mousseau, Antonio Rosal-Vela, Davide Botta, John E Bradley, Wojciech Wojciechowski, Travis Ptacek, Maria I Danila, Jeffrey C Edberg, S Louis Bridges Jr, Robert P Kimberly, W Winn Chatham, Trenton R Schoeb, Alexander F Rosenberg, Jeremy M Boss, Ignacio Sanz, Frances E Lund
Published 2019-05-01

Balancing Selection on a Regulatory Region Exhibiting Ancient Variation That Predates Human–Neandertal Divergence

by Gokcumen, Omer, Zhu, Qihui, Mulder, Lubbertus C. F., Iskow, Rebecca C., Austermann, Christian, Scharer, Christopher D., Raj, Towfique, Boss, Jeremy M., Sunyaev, Shamil R., Price, Alkes, Stranger, Barbara, Simon, Viviana, Lee, Charles
Published 2013