Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling

by Miguel A. Minaya, Sidhartha Mahali, Abhirami K. Iyer, Abdallah M. Eteleeb, Rita Martinez, Guangming Huang, John Budde, Sally Temple, Alissa L. Nana, William W. Seeley, Salvatore Spina, Lea T. Grinberg, Lea T. Grinberg, Oscar Harari, Oscar Harari, Oscar Harari, Celeste M. Karch, Celeste M. Karch, Celeste M. Karch
Published 2023-02-01

Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains.

by Celeste M Karch, Amanda T Jeng, Petra Nowotny, Janet Cady, Carlos Cruchaga, Alison M Goate
Published 2012-01-01

Soluble TREM2: Innocent bystander or active player in neurological diseases?

by Fabia Filipello, Claire Goldsbury, Shih Feng You, Alberto Locca, Celeste M. Karch, Laura Piccio
Published 2022-04-01

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the London mutation in APP (V717I)

by Damián Hernández, Stephanie Morgan Schlicht, Maciej Daniszewski, Celeste M. Karch, Alison M. Goate, Alice Pébay
Published 2021-05-01

Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer’s disease

by Fuhai Li, Fuhai Li, Fuhai Li, Abdallah M. Eteleeb, Abdallah M. Eteleeb, Abdallah M. Eteleeb, William Buchser, Christopher Sohn, Christopher Sohn, Christopher Sohn, Guoqiao Wang, Chengjie Xiong, Philip R. Payne, Eric McDade, Celeste M. Karch, Celeste M. Karch, Celeste M. Karch, Oscar Harari, Oscar Harari, Oscar Harari, Carlos Cruchaga, Carlos Cruchaga, Carlos Cruchaga
Published 2022-09-01

Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.

by Celeste M Karch, Lubov A Ezerskiy, Sarah Bertelsen, Alzheimer’s Disease Genetics Consortium (ADGC), Alison M Goate
Published 2016-01-01

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

by Daniel L Kober, Jennifer M Alexander-Brett, Celeste M Karch, Carlos Cruchaga, Marco Colonna, Michael J Holtzman, Thomas J Brett
Published 2016-12-01

Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2

by Simon Hsu, Anna A. Pimenova, Kimberly Hayes, Juan A. Villa, Matthew J. Rosene, Madhavi Jere, Alison M. Goate, Celeste M. Karch
Published 2020-06-01

Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration

by Sidhartha Mahali, Rita Martinez, Melvin King, Anthony Verbeck, Oscar Harari, Bruno A. Benitez, Kanta Horie, Chihiro Sato, Sally Temple, Celeste M. Karch
Published 2022-12-01

Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice.

by Abhirami K Iyer, Kathleen M Schoch, Anthony Verbeck, Grant Galasso, Hao Chen, Sarah Smith, Anna Oldenborg, Timothy M Miller, Celeste M Karch, Azad Bonni
Published 2023-01-01

Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction

by Lubov A. Ezerskiy, Kathleen M. Schoch, Chihiro Sato, Mariana Beltcheva, Kanta Horie, Frank Rigo, Ryan Martynowicz, Celeste M. Karch, Randall J. Bateman, Timothy M. Miller
Published 2022-01-01

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

by Chao Wang, Michael E. Ward, Robert Chen, Kai Liu, Tara E. Tracy, Xu Chen, Min Xie, Peter Dongmin Sohn, Connor Ludwig, Anke Meyer-Franke, Celeste M. Karch, Sheng Ding, Li Gan
Published 2017-10-01

Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.

by John S K Kauwe, Carlos Cruchaga, Celeste M Karch, Brooke Sadler, Mo Lee, Kevin Mayo, Wayne Latu, Manti Su'a, Anne M Fagan, David M Holtzman, John C Morris, Alzheimer's Disease Neuroimaging Initiative, Alison M Goate
Published 2011-02-01

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

by Julia TCW, Minghui Wang, Anna A. Pimenova, Kathryn R. Bowles, Brigham J. Hartley, Emre Lacin, Saima I. Machlovi, Rawan Abdelaal, Celeste M. Karch, Hemali Phatnani, Paul A. Slesinger, Bin Zhang, Alison M. Goate, Kristen J. Brennand
Published 2017-08-01

Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models

by James A. Gregory, Emily Hoelzli, Rawan Abdelaal, Catherine Braine, Miguel Cuevas, Madeline Halpern, Natalie Barretto, Nadine Schrode, Güney Akbalik, Kristy Kang, Esther Cheng, Kathryn Bowles, Steven Lotz, Susan Goderie, Celeste M. Karch, Sally Temple, Alison Goate, Kristen J. Brennand, Hemali Phatnani
Published 2020-06-01

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

by Zeran Li, Jorge L. Del-Aguila, Umber Dube, John Budde, Rita Martinez, Kathleen Black, Qingli Xiao, Nigel J. Cairns, The Dominantly Inherited Alzheimer Network (DIAN), Joseph D. Dougherty, Jin-Moo Lee, John C. Morris, Randall J. Bateman, Celeste M. Karch, Carlos Cruchaga, Oscar Harari
Published 2018-06-01

The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers.

by Bruno A Benitez, Celeste M Karch, Yefei Cai, Sheng Chih Jin, Breanna Cooper, David Carrell, Sarah Bertelsen, Lori Chibnik, Julie A Schneider, David A Bennett, Alzheimer's Disease Neuroimaging Initiative, Genetic and Environmental Risk for Alzheimer's Disease Consortium GERAD, Anne M Fagan, David Holtzman, John C Morris, Alison M Goate, Carlos Cruchaga
Published 2013-01-01

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

by Celeste M. Karch, Damián Hernández, Jen-Chyong Wang, Jacob Marsh, Alex W. Hewitt, Simon Hsu, Joanne Norton, Denise Levitch, Tamara Donahue, Wendy Sigurdson, Bernardino Ghetti, Martin Farlow, Jasmeer Chhatwal, Sarah Berman, Carlos Cruchaga, John C. Morris, Randall J. Bateman, the Dominantly Inherited Alzheimer Network (DIAN), Alice Pébay, Alison M. Goate
Published 2018-07-01

Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease.

by Abdallah M Eteleeb, Brenna C Novotny, Carolina Soriano Tarraga, Christopher Sohn, Eliza Dhungel, Logan Brase, Aasritha Nallapu, Jared Buss, Fabiana Farias, Kristy Bergmann, Joseph Bradley, Joanne Norton, Jen Gentsch, Fengxian Wang, Albert A Davis, John C Morris, Celeste M Karch, Richard J Perrin, Bruno A Benitez, Oscar Harari
Published 2024-04-01

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

by Daniel Twohig, Elena Rodriguez-Vieitez, Sigrid B. Sando, Guro Berge, Camilla Lauridsen, Ina Møller, Gøril R. Grøntvedt, Geir Bråthen, Kalicharan Patra, Guojun Bu, Tammie L. S. Benzinger, Celeste M. Karch, Anne Fagan, John C. Morris, Randall J. Bateman, Agneta Nordberg, Linda R. White, Henrietta M. Nielsen, for the Dominantly Inherited Alzheimer Network (DIAN)
Published 2018-11-01