Predicting the next move: tracking the complexity of lung cancer evolution and metastasis

by Carina Lorenz, Axel M. Hillmer, Johannes Brägelmann
Published 2023-08-01

AI-based multi-PRS models outperform classical single-PRS models

by Jan Henric Klau, Carlo Maj, Hannah Klinkhammer, Hannah Klinkhammer, Peter M. Krawitz, Andreas Mayr, Axel M. Hillmer, Johannes Schumacher, Dominik Heider
Published 2023-06-01

Trophoblast Cell Surface Antigen 2 (TROP2) as a Predictive Bio-Marker for the Therapeutic Efficacy of Sacituzumab Govitecan in Adenocarcinoma of the Esophagus

by Sascha Hoppe, Lydia Meder, Florian Gebauer, Roland T. Ullrich, Thomas Zander, Axel M. Hillmer, Reinhard Buettner, Patrick Plum, Julian Puppe, Wolfram Malter, Alexander Quaas
Published 2022-09-01

Why loss of Y? A pan-cancer genome analysis of tumors with loss of Y chromosome

by Philipp Müller, Oscar Velazquez Camacho, Ali M. Yazbeck, Christina Wölwer, Weiwei Zhai, Johannes Schumacher, Dominik Heider, Reinhard Buettner, Alexander Quaas, Axel M. Hillmer
Published 2023-01-01

Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

by Carina Heydt, Jan Rehker, Roberto Pappesch, Theresa Buhl, Markus Ball, Udo Siebolts, Anja Haak, Philipp Lohneis, Reinhard Büttner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Published 2020-07-01

Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma

by Simon Schallenberg, Julian Bork, Ahlem Essakly, Hakan Alakus, Reinhard Buettner, Axel M. Hillmer, Christiane Bruns, Wolfgang Schroeder, Thomas Zander, Heike Loeser, Florian Gebauer, Alexander Quaas
Published 2020-01-01

Y Chromosome Loss Is a Frequent Event in Barrett’s Adenocarcinoma and Associated with Poor Outcome

by Heike Loeser, Christina B. Wölwer, Hakan Alakus, Seung-Hun Chon, Thomas Zander, Reinhard Buettner, Axel M. Hillmer, Christiane J. Bruns, Wolfgang Schroeder, Florian Gebauer, Alexander Quaas
Published 2020-06-01

Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cance...

by Say Li Kong, Xingliang Liu, Swee Jin Tan, Joyce A. Tai, Ler Yee Phua, Huay Mei Poh, Trifanny Yeo, Yong Wei Chua, Yu Xuan Haw, Wen Huan Ling, Raymond Chee Hui Ng, Raymond Chee Hui Ng, Tira J. Tan, Tira J. Tan, Kiley Wei Jen Loh, Daniel Shao-Weng Tan, Quan Sing Ng, Mei Kim Ang, Chee Keong Toh, Yi Fang Lee, Chwee Teck Lim, Tony Kiat Hon Lim, Axel M. Hillmer, Axel M. Hillmer, Axel M. Hillmer, Yoon Sim Yap, Yoon Sim Yap, Wan-Teck Lim, Wan-Teck Lim, Wan-Teck Lim
Published 2021-07-01

PIK3CA and KRAS Amplification in Esophageal Adenocarcinoma and their Impact on the Inflammatory Tumor Microenvironment and Prognosis

by Ahlem Essakly, Heike Loeser, Max Kraemer, Hakan Alakus, Seung-Hun Chon, Thomas Zander, Reinhard Buettner, Axel M. Hillmer, Christiane J. Bruns, Wolfgang Schroeder, Florian Gebauer, Alexander Quaas
Published 2020-02-01

Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer

by Chenghui Zhou, Ningbo Fan, Fanyu Liu, Nan Fang, Patrick S. Plum, René Thieme, Ines Gockel, Sascha Gromnitza, Axel M. Hillmer, Seung-Hun Chon, Hans A. Schlösser, Christiane J. Bruns, Yue Zhao
Published 2020-06-01

Amplification of KRAS and its heterogeneity in non-Asian gastric adenocarcinomas

by Jan Rehkaemper, Michael Korenkov, Alexander Quaas, Josef Rueschoff, Aylin Pamuk, Thomas Zander, Axel M. Hillmer, Reinhard Buettner, Arnulf Heinrich Hoelscher, Christiane Josephine Bruns, Heike Loeser, Hakan Alakus, Birgid Schoemig-Markiefka
Published 2020-06-01

Aldo-Keto Reductase 1C3 Mediates Chemotherapy Resistance in Esophageal Adenocarcinoma via ROS Detoxification

by Chenghui Zhou, Zhefang Wang, Jiahui Li, Xiaolin Wu, Ningbo Fan, Dai Li, Fanyu Liu, Patrick S. Plum, Sascha Hoppe, Axel M. Hillmer, Alexandar Quaas, Florian Gebauer, Seung-Hun Chon, Christiane J. Bruns, Yue Zhao
Published 2021-05-01

Experimental and bioinformatics considerations in cancer application of single cell genomics

by Joanna Hui Juan Tan, Say Li Kong, Joyce A. Tai, Huay Mei Poh, Fei Yao, Yee Yen Sia, Edwin Kok Hao Lim, Angela Maria Takano, Daniel Shao-Weng Tan, Asif Javed, Axel M. Hillmer
Published 2021-01-01

Tumor phylogeography reveals block-shaped spatial heterogeneity and the mode of evolution in Hepatocellular Carcinoma

by Xiaodong Liu, Ke Zhang, Neslihan A. Kaya, Zhe Jia, Dafei Wu, Tingting Chen, Zhiyuan Liu, Sinan Zhu, Axel M. Hillmer, Torsten Wuestefeld, Jin Liu, Yun Shen Chan, Zheng Hu, Liang Ma, Li Jiang, Weiwei Zhai
Published 2024-04-01

Variant profiling of colorectal adenomas from three patients of two families with MSH3-related adenomatous polyposis.

by Claudia Perne, Sophia Peters, Maria Cartolano, Sukanya Horpaopan, Christina Grimm, Janine Altmüller, Anna K Sommer, Axel M Hillmer, Holger Thiele, Margarete Odenthal, Gabriela Möslein, Ronja Adam, Sugirthan Sivalingam, Jutta Kirfel, Michal R Schweiger, Martin Peifer, Isabel Spier, Stefan Aretz
Published 2021-01-01

Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced using CD40-activated B cells

by Alexander Quaas, Hans Anton Schlößer, Michael von Bergwelt-Baildon, Martin Thelen, Birgit Gathof, Axel M Hillmer, Christiane Bruns, Diandra Keller, Jonas Lehmann, Kerstin Wennhold, Hendrik Weitz, Eugen Bauer, Monika Brüggemann, Michaela Kotrova, Christoph Mallmann, Seung-Hun Chon, Maria Alejandra Garcia-Marquez
Published 2022-12-01

Cell type‐specific transcriptomics of esophageal adenocarcinoma as a scalable alternative for single cell transcriptomics

by Max Krämer, Patrick S. Plum, Oscar Velazquez Camacho, Kat Folz‐Donahue, Martin Thelen, Isabel Garcia‐Marquez, Christina Wölwer, Sören Büsker, Jana Wittig, Marek Franitza, Janine Altmüller, Heike Löser, Hans Schlößer, Reinhard Büttner, Wolfgang Schröder, Christiane J. Bruns, Hakan Alakus, Alexander Quaas, Seung‐Hun Chon, Axel M. Hillmer
Published 2020-06-01

Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation

by Carina Heydt, Christina B. Wölwer, Oscar Velazquez Camacho, Svenja Wagener-Ryczek, Roberto Pappesch, Janna Siemanowski, Jan Rehker, Florian Haller, Abbas Agaimy, Karl Worm, Thomas Herold, Nicole Pfarr, Wilko Weichert, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Wolfgang Goering, Irene Esposito, Reinhard Buettner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Published 2021-02-01

Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides

by Alexander Quaas, Julie George, Philipp Müller, Hans Anton Schlößer, Michael von Bergwelt-Baildon, Martin Thelen, Birgit Gathof, Martin Peifer, Thomas Zander, Axel M Hillmer, Christiane Bruns, Diandra Keller, Jonas Lehmann, Kerstin Wennhold, Eugen Bauer, Maria Alejandra Garcia-Marquez, Roman Thomas, Lukas Maas, Miloš Nikolić, Wolfgang Schröder, Ali M Yazbeck
Published 2024-04-01

Comparing genomic landscape of early stage, treatment naïve and late stage, drug resistant EGFR-mutant lung adenocarcinomas

by Rahul Nahar, Yin Yeng Lee, Alexis J. Khng, Tong Zhang, Angela Takano, Xingliang Liu, Jacob J.S. Alvarez, Ori Zelichov, Ezra Ella, Zohar Barbash, Chong Hee Lim, Tina P.T. Koh, Zaw Win Aung, Tony Kiat Hon Lim, Chee Keong Toh, Wan-Teck Lim, Bing Lim, Wai Leong Tam, Eng-Huat Tan, Weiwei Zhai, Daniel S.W. Tan, Axel M. Hillmer
Published 2017-12-01