Challenges in studying geographic atrophy (GA) age-related macular degeneration: the potential of a new mouse model with GA-like features

by J Arjuna Ratnayaka, Andrew J Lotery
Published 2020-01-01

Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment

by Adnan H. Khan, Itay Chowers, Andrew J. Lotery
Published 2023-06-01

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases

by Eloise Keeling, Andrew J. Lotery, David A. Tumbarello, J. Arjuna Ratnayaka
Published 2018-02-01

Treatment Satisfaction and Well-Being in Patients with Myopic Choroidal Neovascularization Treated with Ranibizumab in the REPAIR Study.

by Winfried M Amoaku, Richard P Gale, Andrew J Lotery, Geeta Menon, Sobha Sivaprasad, Jennifer Petrillo, Jennifer Quinn
Published 2015-01-01

Multimodal Imaging in the Management of Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy

by Ahmed M. Hagag, Shruti Chandra, Hagar Khalid, Ali Lamin, Pearse A. Keane, Andrew J. Lotery, Sobha Sivaprasad
Published 2020-06-01

The complexities underlying age-related macular degeneration: could amyloid beta play an important role?

by Savannah A Lynn, Eloise Keeling, Rosie Munday, Gagandeep Gabha, Helen Griffiths, Andrew J Lotery, J Arjuna Ratnayaka
Published 2017-01-01

Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort

by Rebecca A. Kaye, Karina Patasova, Praveen J. Patel, Pirro Hysi, Andrew J. Lotery, The UK Biobank Eye and Vision Consortium
Published 2021-12-01

An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy

by Eloise Keeling, Annabelle J. Culling, David A. Johnston, David S. Chatelet, Anton Page, David A. Tumbarello, Andrew J. Lotery, J. Arjuna Ratnayaka
Published 2020-09-01

A novel, wearable, electronic visual aid to assist those with reduced peripheral vision.

by Ffion E Brown, Janice Sutton, Ho M Yuen, Dylan Green, Spencer Van Dorn, Terry Braun, Angela J Cree, Stephen R Russell, Andrew J Lotery
Published 2019-01-01

Characterization of the Frmd7 Knock-Out Mice Generated by the EUCOMM/COMP Repository as a Model for Idiopathic Infantile Nystagmus (IIN)

by Ahmed Salman, Samuel B. Hutton, Tutte Newall, Jennifer A. Scott, Helen L. Griffiths, Helena Lee, Diego Gomez-Nicola, Andrew J. Lotery, Jay E. Self
Published 2020-09-01

A laser-induced mouse model of progressive retinal degeneration with central sparing displays features of parafoveal geographic atrophy

by Adnan H. Khan, Sudha Priya Soundara Pandi, Jennifer A. Scott, Aida Sánchez-Bretaño, Savannah A. Lynn, J. Arjuna Ratnayaka, Jessica L. Teeling, Andrew J. Lotery
Published 2023-03-01

3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina

by Eloise Keeling, David S. Chatelet, Nicole Y. T. Tan, Farihah Khan, Rhys Richards, Thibana Thisainathan, Patricia Goggin, Anton Page, David A. Tumbarello, Andrew J. Lotery, J. Arjuna Ratnayaka
Published 2020-11-01

A convenient protocol for establishing a human cell culture model of the outer retina. [version 1; referees: 2 approved]

by Savannah A. Lynn, Eloise Keeling, Jennifer M. Dewing, David A. Johnston, Anton Page, Angela J. Cree, David A. Tumbarello, Tracey A. Newman, Andrew J. Lotery, J. Arjuna Ratnayaka
Published 2018-07-01

AAV2/8 Anti-angiogenic Gene Therapy Using Single-Chain Antibodies Inhibits Murine Choroidal Neovascularization

by Chris P. Hughes, Neil M.J. O’Flynn, Maureen Gatherer, Michelle E. McClements, Jennifer A. Scott, Robert E. MacLaren, Srinivas Goverdhan, Martin J. Glennie, Andrew J. Lotery
Published 2019-06-01

Human equivalent doses of l-DOPA rescues retinal morphology and visual function in a murine model of albinism

by Aida Sanchez-Bretano, Eloise Keeling, Jennifer A. Scott, Savannah A. Lynn, Sudha Priya Soundara-Pandi, Sarah L. Macdonald, Tutte Newall, Helen Griffiths, Andrew J. Lotery, J. Arjuna Ratnayaka, Jay E. Self, Helena Lee
Published 2023-10-01

An Exploratory Study Provides Insights into MMP9 and Aβ Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients

by Savannah A. Lynn, Flavie Soubigou, Jennifer M. Dewing, Amanda Smith, Joanna Ballingall, Thea Sass, Isabela Nica, Catrin Watkins, Bhaskar Gupta, Hussein Almuhtaseb, Stephen C. Lash, Ho Ming Yuen, Angela Cree, Tracey A. Newman, Andrew J. Lotery, J. Arjuna Ratnayaka
Published 2022-11-01

A small gene sequencing panel realises a high diagnostic rate in patients with congenital nystagmus following basic phenotyping

by Luke O’Gorman, Chelsea S. Norman, Luke Michaels, Tutte Newall, Andrew H. Crosby, Christopher Mattocks, Angela J. Cree, Andrew J. Lotery, Emma L. Baple, J. Arjuna Ratnayaka, Diana Baralle, Helena Lee, Daniel Osborne, Fatima Shawkat, Jane Gibson, Sarah Ennis, Jay E. Self
Published 2019-09-01

A randomised controlled trial to assess the clinical effectiveness and cost-effectiveness of alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVA...

by Usha Chakravarthy, Simon P Harding, Chris A Rogers, Susan Downes, Andrew J Lotery, Helen A Dakin, Lucy Culliford, Lauren J Scott, Rachel L Nash, Jodi Taylor, Alyson Muldrew, Jayashree Sahni, Sarah Wordsworth, James Raftery, Tunde Peto, Barnaby C Reeves, for the IVAN Investigators
Published 2015-10-01

Oligomeric Aβ_1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function

by Savannah A. Lynn, David A. Johnston, Jenny A. Scott, Rosie Munday, Roshni S. Desai, Eloise Keeling, Ruaridh Weaterton, Alexander Simpson, Dillon Davis, Thomas Freeman, David S. Chatelet, Anton Page, Angela J. Cree, Helena Lee, Tracey A. Newman, Andrew J. Lotery, J. Arjuna Ratnayaka
Published 2021-02-01

The STArgardt Remofuscin Treatment Trial (STARTT): design and baseline characteristics of enrolled Stargardt patients [version 3; peer review: 2 approved]

by Philipp T. Möller, Patty P.A. Dhooge, Andrew J. Lotery, Camiel J.F. Boon, Maurizio Battaglia Parodi, Philipp Herrmann, Mario G. Fsadni, Wolfgang Klein, Oliver Jungmann, Thomas H. Wheeler-Schilling, Frank G. Holz, Hans Müller, Tobias M. Peters, Steffen Schmitz-Valckenberg, Carel B. Hoyng, Katarina Stingl
Published 2022-09-01