CRISPR DNA Base Editing Strategies for Treating Retinitis Pigmentosa Caused by Mutations in <i>Rhodopsin</i>

by Maria Kaukonen, Michelle E. McClements, Robert E. MacLaren
Published 2022-07-01

CRISPR Manipulation of Age-Related Macular Degeneration Haplotypes in the Complement System: Potential Future Therapeutic Applications/Avenues

by Ahmed Salman, Michelle E. McClements, Robert E. MacLaren
Published 2024-01-01

A Review of CRISPR Tools for Treating Usher Syndrome: Applicability, Safety, Efficiency, and In Vivo Delivery

by Lauren Major, Michelle E. McClements, Robert E. MacLaren
Published 2023-04-01

CRISPR-Cas9 DNA Base-Editing and Prime-Editing

by Ariel Kantor, Michelle E. McClements, Robert E. MacLaren
Published 2020-08-01

New CRISPR Tools to Correct Pathogenic Mutations in Usher Syndrome

by Lauren Major, Michelle E. McClements, Robert E. MacLaren
Published 2022-10-01

Therapy Approaches for Stargardt Disease

by Elena Piotter, Michelle E McClements, Robert E MacLaren
Published 2021-08-01

Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina

by Ahmed Salman, Michelle E. McClements, Robert E. MacLaren
Published 2021-07-01

Minicircle Delivery to the Neural Retina as a Gene Therapy Approach

by Federica Staurenghi, Michelle E. McClements, Ahmed Salman, Robert E. MacLaren
Published 2022-10-01

Future Perspectives of Prime Editing for the Treatment of Inherited Retinal Diseases

by Silja Hansen, Michelle E. McClements, Thomas J. Corydon, Robert E. MacLaren
Published 2023-01-01

CRISPR Interference–Potential Application in Retinal Disease

by Caroline F. Peddle, Lewis E. Fry, Michelle E. McClements, Robert E. MacLaren
Published 2020-03-01

The Scope of Pathogenic ABCA4 Mutations Targetable by CRISPR DNA Base Editing Systems—A Systematic Review

by Elena Piotter, Michelle E. McClements, Robert E. MacLaren, Robert E. MacLaren
Published 2022-01-01

Accurate Quantification of AAV Vector Genomes by Quantitative PCR

by Cristina Martinez-Fernandez de la Camara, Michelle E. McClements, Robert E. MacLaren
Published 2021-04-01

Non-Viral Delivery of CRISPR/Cas Cargo to the Retina Using Nanoparticles: Current Possibilities, Challenges, and Limitations

by Ahmed Salman, Ariel Kantor, Michelle E. McClements, Gemma Marfany, Sonia Trigueros, Robert E. MacLaren
Published 2022-09-01

In Silico Analysis of Pathogenic <i>CRB1</i> Single Nucleotide Variants and Their Amenability to Base Editing as a Potential Lead for Therapeutic Intervention

by Julia-Sophia Bellingrath, Michelle E. McClements, Maria Kaukonen, Manuel Dominik Fischer, Robert E. MacLaren
Published 2021-11-01

Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina

by Maria I. Patrício, Alun R. Barnard, Harry O. Orlans, Michelle E. McClements, Robert E. MacLaren
Published 2017-03-01

RNA Editing as a Therapeutic Approach for Retinal Gene Therapy Requiring Long Coding Sequences

by Lewis E. Fry, Caroline F. Peddle, Alun R. Barnard, Michelle E. McClements, Robert E. MacLaren
Published 2020-01-01

Molecular Strategies for RPGR Gene Therapy

by Jasmina Cehajic Kapetanovic, Michelle E McClements, Cristina Martinez-Fernandez de la Camara, Robert E MacLaren
Published 2019-09-01

Analysis of Early Cone Dysfunction in an In Vivo Model of Rod-Cone Dystrophy

by Mark M. Hassall, Michelle E. McClements, Alun R. Barnard, Maria I. Patrício, Sher A. Aslam, Robert E. Maclaren
Published 2020-08-01

Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy

by Laurel C. Chandler, Imran H. Yusuf, Michelle E. McClements, Alun R. Barnard, Robert E. MacLaren, Kanmin Xue
Published 2020-07-01

Optogenetic Gene Therapy for the Degenerate Retina: Recent Advances

by Michelle E. McClements, Federica Staurenghi, Robert E. MacLaren, Robert E. MacLaren, Jasmina Cehajic-Kapetanovic, Jasmina Cehajic-Kapetanovic
Published 2020-11-01