How Arrestins and GRKs Regulate the Function of Long Chain Fatty Acid Receptors

by Abdulrahman G. Alharbi, Andrew B. Tobin, Graeme Milligan
Published 2022-10-01

ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment.

by Guzmán Sánchez-Fernández, Sofía Cabezudo, Carlota García-Hoz, Andrew B Tobin, Federico Mayor, Catalina Ribas
Published 2013-01-01

A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia

by Brian Dean, Geor Bakker, Hiroki R. Ueda, Hiroki R. Ueda, Andrew B. Tobin, Alastair Brown, Richard A. A. Kanaan
Published 2023-02-01

Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation.

by Michele Graciotti, Mahmood Alam, Lev Solyakov, Ralf Schmid, Glenn Burley, Andrew R Bottrill, Christian Doerig, Paul Cullis, Andrew B Tobin
Published 2014-01-01

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

by Emma T. van der Westhuizen, K. H. Christopher Choy, Celine Valant, Simon McKenzie-Nickson, Sophie J. Bradley, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos
Published 2021-01-01

Chemogenetics defines a short-chain fatty acid receptor gut–brain axis

by Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Published 2022-03-01

Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner

by Natasja Barki, Laura Jenkins, Sara Marsango, Domonkos Dedeo, Daniele Bolognini, Louis Dwomoh, Aisha M Abdelmalik, Margaret Nilsen, Manon Stoffels, Falko Nagel, Stefan Schulz, Andrew B Tobin, Graeme Milligan
Published 2023-12-01

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

by David S Guttery, David J P Ferguson, Benoit Poulin, Zhengyao Xu, Ursula Straschil, Onny Klop, Lev Solyakov, Sara M Sandrini, Declan Brady, Conrad A Nieduszynski, Chris J Janse, Anthony A Holder, Andrew B Tobin, Rita Tewari
Published 2012-02-01

Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission.

by Selina Kern, Shruti Agarwal, Kilian Huber, André P Gehring, Benjamin Strödke, Christine C Wirth, Thomas Brügl, Liliane Onambele Abodo, Thomas Dandekar, Christian Doerig, Rainer Fischer, Andrew B Tobin, Mahmood M Alam, Franz Bracher, Gabriele Pradel
Published 2014-01-01

Correction: A Putative Homologue of CDC20/CDH1 in the Malaria Parasite Is Essential for Male Gamete Development.

by David S. Guttery, David J. P. Ferguson, Benoit Poulin, Zhengyao Xu, Ursula Straschil, Onny Klop, Lev Solyakov, Sara M. Sandrini, Declan Brady, Conrad A. Nieduszynski, Chris J. Janse, Anthony A. Holder, Andrew B. Tobin, Rita Tewari
Published 2012-03-01

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

by Sachel Mok, Barbara H. Stokes, Nina F. Gnädig, Leila S. Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R. Bottrill, Jaishree Tripathi, Rick M. Fairhurst, Manuel Llinás, Zbynek Bozdech, Andrew B. Tobin, David A. Fidock
Published 2021-01-01

Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction.

by Amit Mahindra, Gonzalo Tejeda, Mario Rossi, Omar Janha, Imogen Herbert, Caroline Morris, Danielle C Morgan, Wendy Beattie, Augusto C Montezano, Brian Hudson, Andrew B Tobin, David Bhella, Rhian M Touyz, Andrew G Jamieson, George S Baillie, Connor M Blair
Published 2021-01-01

Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction

by Amit Mahindra, Gonzalo Tejeda, Mario Rossi, Omar Janha, Imogen Herbert, Caroline Morris, Danielle C. Morgan, Wendy Beattie, Augusto C. Montezano, Brian Hudson, Andrew B. Tobin, David Bhella, Rhian M. Touyz, Andrew G. Jamieson, George S. Baillie, Connor M. Blair
Published 2021-01-01

A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion.

by David S Guttery, Benoit Poulin, David J P Ferguson, Balázs Szöőr, Bill Wickstead, Paula L Carroll, Chandra Ramakrishnan, Declan Brady, Eva-Maria Patzewitz, Ursula Straschil, Lev Solyakov, Judith L Green, Robert E Sinden, Andrew B Tobin, Anthony A Holder, Rita Tewari
Published 2012-09-01

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

by Wessel A. C. Burger, Vi Pham, Ziva Vuckovic, Alexander S. Powers, Jesse I. Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B. Tobin, Patrick M. Sexton, Steven M. Paul, Christian C. Felder, Radostin Danev, Ron O. Dror, Arthur Christopoulos, Celine Valant, David M. Thal
Published 2023-09-01

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.

by Irene Fasciani, Francesco Petragnano, Ziming Wang, Ruairidh Edwards, Narasimha Telugu, Ilaria Pietrantoni, Ulrike Zabel, Henrik Zauber, Marlies Grieben, Maria E Terzenidou, Jacopo Di Gregorio, Cristina Pellegrini, Silvano Santini, Anna R Taddei, Bärbel Pohl, Stefano Aringhieri, Marco Carli, Gabriella Aloisi, Francesco Marampon, Eve Charlesworth, Alexandra Roman, Sebastian Diecke, Vincenzo Flati, Franco Giorgi, Fernanda Amicarelli, Andrew B Tobin, Marco Scarselli, Kostas Tokatlidis, Mario Rossi, Martin J Lohse, Paolo Annibale, Roberto Maggio
Published 2024-04-01