Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.

by Jesse I Mobbs, Matthew J Belousoff, Kaleeckal G Harikumar, Sarah J Piper, Xiaomeng Xu, Sebastian G B Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M Thal, Laurence J Miller, Patrick M Sexton
Published 2021-06-01

Structural and regulatory diversity shape HLA-C protein expression levels

by Gurman Kaur, Stephanie Gras, Jesse I. Mobbs, Julian P. Vivian, Adrian Cortes, Thomas Barber, Subita Balaram Kuttikkatte, Lise Torp Jensen, Kathrine E. Attfield, Calliope A. Dendrou, Mary Carrington, Gil McVean, Anthony W. Purcell, Jamie Rossjohn, Lars Fugger
Published 2017-06-01

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

by Wessel A. C. Burger, Vi Pham, Ziva Vuckovic, Alexander S. Powers, Jesse I. Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B. Tobin, Patrick M. Sexton, Steven M. Paul, Christian C. Felder, Radostin Danev, Ron O. Dror, Arthur Christopoulos, Celine Valant, David M. Thal
Published 2023-09-01

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

by Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I Mobbs, Matthew J Belousoff, Apurba Bhattarai, Wessel AC Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W Lindsley, Andrew Tobin, Patrick Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David M Thal
Published 2023-05-01