Towards clinical implementation of circulating tumor DNA in metastatic prostate cancer: Opportunities for integration and pitfalls to interpretation

by Edmond M. Kwan, Edmond M. Kwan, Alexander W. Wyatt, Alexander W. Wyatt, Kim N. Chi, Kim N. Chi, Kim N. Chi
Published 2022-11-01

Development of secondary urothelial carcinoma following complete response to immune checkpoint inhibitors

by Jean-Michel Lavoie, Gillian Vandekerkhove, Andrew J. Murtha, Gang Wang, Alexander W. Wyatt, Bernhard J. Eigl
Published 2021-11-01

A meta-analysis approach for characterizing pan-cancer mechanisms of drug sensitivity in cell lines.

by Kendric Wang, Raunak Shrestha, Alexander W Wyatt, Anupama Reddy, Joseph Lehár, Yuzhou Wang, Anna Lapuk, Colin C Collins
Published 2014-01-01

Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer

by David Gonzalez, Joaquin Mateo, Albrecht Stenzinger, Federico Rojo, Michelle Shiller, Alexander W Wyatt, Frédérique Penault‐Llorca, Leonard G Gomella, Ros Eeles, Anders Bjartell
Published 2021-07-01

Circulating Tumor Cells (CTC) and Cell-Free DNA (cfDNA) Workshop 2016: Scientific Opportunities and Logistics for Cancer Clinical Trial Incorporation

by Lori E. Lowes, Scott V. Bratman, Ryan Dittamore, Susan Done, Shana O. Kelley, Sabine Mai, Ryan D. Morin, Alexander W. Wyatt, Alison L. Allan
Published 2016-09-01

Next generation patient-derived prostate cancer xenograft models

by Dong Lin, Hui Xue, Yuwei Wang, Rebecca Wu, Akira Watahiki, Xin Dong, Hongwei Cheng, Alexander W Wyatt, Colin C Collins, Peter W Gout, Yuzhuo Wang
Published 2014-06-01

Systematic identification and characterization of RNA editing in prostate tumors.

by Fan Mo, Alexander W Wyatt, Yue Sun, Sonal Brahmbhatt, Brian J McConeghy, Chunxiao Wu, Yuzhuo Wang, Martin E Gleave, Stanislav V Volik, Colin C Collins
Published 2014-01-01

A genome-wide CRISPR screen maps endogenous regulators of PPARG gene expression in bladder cancer

by Davide Tortora, Morgan E. Roberts, Gunjan Kumar, Sudha S. Kotapalli, Elie Ritch, Joshua M. Scurll, Brian McConeghy, Sunita Sinha, Alexander W. Wyatt, Peter C. Black, Mads Daugaard
Published 2023-05-01

A generalizable machine learning framework for classifying DNA repair defects using ctDNA exomes

by Elie J. Ritch, Cameron Herberts, Evan W. Warner, Sarah W. S. Ng, Edmond M. Kwan, Jack V. W. Bacon, Cecily Q. Bernales, Elena Schönlau, Nicolette M. Fonseca, Veda N. Giri, Corinne Maurice-Dror, Gillian Vandekerkhove, Steven J. M. Jones, Kim N. Chi, Alexander W. Wyatt
Published 2023-03-01

Cell-free DNA concentration and fragment size as a biomarker for prostate cancer

by Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen Lopez, César P. Márquez, Carissa Chu, Patricia S. Li, Erica Oropeza, Imelda Tenggara, Janet Cowan, Jeffry P. Simko, June M. Chan, Terence Friedlander, Alexander W. Wyatt, Rahul Aggarwal, Pamela L. Paris, Peter R. Carroll, Felix Feng, John S. Witte
Published 2021-03-01

B2B: Prostate Cancer Summary

by Stacy Loeb, Peter C. Black, Alexander W. Wyatt, Yaw A. Nyame, Neal Shore, Derya Tilki, Elena Castro, Matthew Cooperberg, Veda Giri, Maria J. Ribal, Giovanni Lughezzani, Rafael Sánchez-Salas, Caroline M. Moore, Art Rastinehad, Linda Kerkmeijer, Hashim U. Ahmed, Shusuke Akamatsu, Alexandre de la Taille, Martin Gleave, Simon Tanguay
Published 2021-07-01

Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer

by Gillian Vandekerkhove, Jean-Michel Lavoie, Matti Annala, Andrew J. Murtha, Nora Sundahl, Simon Walz, Takeshi Sano, Sinja Taavitsainen, Elie Ritch, Ladan Fazli, Antonio Hurtado-Coll, Gang Wang, Matti Nykter, Peter C. Black, Tilman Todenhöfer, Piet Ost, Ewan A. Gibb, Kim N. Chi, Bernhard J. Eigl, Alexander W. Wyatt
Published 2021-01-01

The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors

by Sujun Chen, Jessica Petricca, Wenbin Ye, Jiansheng Guan, Yong Zeng, Nicholas Cheng, Linsey Gong, Shu Yi Shen, Junjie T. Hua, Megan Crumbaker, Michael Fraser, Stanley Liu, Scott V. Bratman, Theodorus van der Kwast, Trevor Pugh, Anthony M. Joshua, Daniel D. De Carvalho, Kim N. Chi, Philip Awadalla, Guoli Ji, Felix Feng, Alexander W. Wyatt, Housheng Hansen He
Published 2022-10-01

The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer

by Shusuke Akamatsu, Alexander W. Wyatt, Dong Lin, Summer Lysakowski, Fan Zhang, Soojin Kim, Charan Tse, Kendric Wang, Fan Mo, Anne Haegert, Sonal Brahmbhatt, Robert Bell, Hans Adomat, Yoshihisa Kawai, Hui Xue, Xin Dong, Ladan Fazli, Harrison Tsai, Tamara L. Lotan, Myriam Kossai, Juan Miguel Mosquera, Mark A. Rubin, Himisha Beltran, Amina Zoubeidi, Yuzhuo Wang, Martin E. Gleave, Colin C. Collins
Published 2015-08-01

Prediction of plasma ctDNA fraction and prognostic implications of liquid biopsy in advanced prostate cancer

by Nicolette M. Fonseca, Corinne Maurice-Dror, Cameron Herberts, Wilson Tu, William Fan, Andrew J. Murtha, Catarina Kollmannsberger, Edmond M. Kwan, Karan Parekh, Elena Schönlau, Cecily Q. Bernales, Gráinne Donnellan, Sarah W. S. Ng, Takayuki Sumiyoshi, Joanna Vergidis, Krista Noonan, Daygen L. Finch, Muhammad Zulfiqar, Stacy Miller, Sunil Parimi, Jean-Michel Lavoie, Edward Hardy, Maryam Soleimani, Lucia Nappi, Bernhard J. Eigl, Christian Kollmannsberger, Sinja Taavitsainen, Matti Nykter, Sofie H. Tolmeijer, Emmy Boerrigter, Niven Mehra, Nielka P. van Erp, Bram De Laere, Johan Lindberg, Henrik Grönberg, Daniel J. Khalaf, Matti Annala, Kim N. Chi, Alexander W. Wyatt
Published 2024-02-01