Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors

by J. Johannes Eksteen, Dominik Ausbacher, Terje Vasskog, Øystein Rekdal, John S. M. Svendsen
Published 2020-03-01

The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.

by Liv-Marie Eike, Brynjar Mauseth, Ketil André Camilio, Øystein Rekdal, Baldur Sveinbjørnsson
Published 2016-01-01

The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma

by Brynjar Mauseth, Ketil André Camilio, Jihua Shi, Clara Louise Hammarström, Øystein Rekdal, Baldur Sveinbjørnsson, Pål-Dag Line
Published 2019-09-01

Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model

by Ketil A. Camilio, Meng-Yu Wang, Brynjar Mauseth, Stein Waagene, Gunnar Kvalheim, Øystein Rekdal, Baldur Sveinbjørnsson, Gunhild M. Mælandsmo
Published 2019-01-01

Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: a case report

by Nina Louise Jebsen, Torunn Oveland Apelseth, Hans Kristian Haugland, Øystein Rekdal, Hamina Patel, Bjørn Tore Gjertsen, Dag Eirik Jøssang
Published 2019-06-01

Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer

by Karianne Giller Fleten, J. Johannes Eksteen, Brynjar Mauseth, Ketil André Camilio, Terje Vasskog, Baldur Sveinbjørnsson, Øystein Rekdal, Gunhild M. Mælandsmo, Kjersti Flatmark
Published 2021-03-01

560 Immunotherapeutic and antimetastatic activity of LTX-315 in preclinical models of ICI-resistant breast cancer

by Xi Zhou, Sandra Demaria, Baldur Sveinbjörnsson, Öystein Rekdal, Erik Wennerberg, Lorenzo Galluzzi, Takahiro Yamazaki, Michal Hensler, Jitka Fucikova, Aitziber Buqué Martinez, Jeffrey Kraynak
Published 2021-11-01

LTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cells

by Takahiro Yamazaki, Erik Wennerberg, Michal Hensler, Aitziber Buqué, Jeffrey Kraynak, Jitka Fucikova, Xi Kathy Zhou, Baldur Sveinbjørnsson, Øystein Rekdal, Sandra Demaria, Lorenzo Galluzzi
Published 2021-01-01

Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model

by Janne Nestvold, Meng-Yu Wang, Ketil A. Camilio, Severin Zinöcker, Torunn Elisabeth Tjelle, Alf Lindberg, Bengt Erik Haug, Gunnar Kvalheim, Baldur Sveinbjørnsson, Øystein Rekdal
Published 2017-08-01

LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects

by Hsin-Wei Liao, Christopher Garris, Christina Pfirschke, Steffen Rickelt, Sean Arlauckas, Marie Siwicki, Rainer H. Kohler, Ralph Weissleder, Vibeke Sundvold-Gjerstad, Baldur Sveinbjørnsson, Øystein Rekdal, Mikael J. Pittet
Published 2019-10-01

Tumor lysis with LTX-401 creates anticancer immunity

by Wei Xie, Laura Mondragón, Brynjar Mauseth, Yan Wang, Jonathan Pol, Sarah Lévesque, Heng Zhou, Takahiro Yamazaki, Johannes J. Eksteen, Laurence Zitvogel, Baldur Sveinbjørnsson, Øystein Rekdal, Oliver Kepp, Guido Kroemer
Published 2019-07-01

LTX-315 triggers anticancer immunity by inducing MyD88-dependent maturation of dendritic cells

by Xiao-Qing Li, Xiao-Qing Li, Takahiro Yamazaki, Tianzhen He, Md Masud Alam, Jia Liu, Anna L. Trivett, Baldur Sveinbjørnsson, Øystein Rekdal, Lorenzo Galluzzi, Lorenzo Galluzzi, Lorenzo Galluzzi, Joost J. Oppenheim, De Yang
Published 2024-03-01

LTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma

by Morten Nielsen, Tine Monberg, Vibeke Sundvold, Benedetta Albieri, Dorrit Hovgaard, Michael Mørk Petersen, Anders Krarup-Hansen, Özcan Met, Ketil Camilio, Trevor Clancy, Richard Stratford, Baldur Sveinbjornsson, Øystein Rekdal, Niels Junker, Inge Marie Svane
Published 2024-12-01

Reimagining Global Oncology Clinical Trials for the Postpandemic Era: A Call to Arms

by Kamal S. Saini, Begoña de las Heras, Ruth Plummer, Victor Moreno, Marco Romano, Javier de Castro, Philippe Aftimos, Judy Fredriksson, Gouri Shankar Bhattacharyya, Martin Sebastian Olivo, Gaia Schiavon, Kevin Punie, Jesus Garcia-Foncillas, Ernesto Rogata, Richie Pfeiffer, Cecilia Orbegoso, Kenneth Morrison, Giuseppe Curigliano, Lynda Chin, Monika Lamba Saini, Øystein Rekdal, Steven Anderson, Javier Cortes, Manuela Leone, Janet Dancey, Chris Twelves, Ahmad Awada
Published 2020-11-01