Recent years we have witnessed major advancements in technologies that support the children that have been diagnosed with the autism by the increasing number of the application to enhance their ability in communication, understanding and interface with others. There are increasing numbers of a new mobile application that can be found on the market today, unfortunately, many of them are difficult to use and learn by the autistic children. This is due to the lack of usability guidelines for mobile application and relatively unexplored and unproven. This research will propose usability guidelines for interface design of mobile application for autism. The objectives of this research are to identify existing usability factors that have been currently used to design the interface of mobile application for autism and to review the usability guideline to design the interface of mobile application for autism. This project will be conducted in three phases and mixed method involving observation and interview will be applied. The finding of this study is to identify compatible usability elements for designing mobile application user interface for autistic children. © 2018 Author(s).