This paper focuses on the influence of interactions on students' academic performance (SAP) in blended and traditional learning delivery. Its objective is to determine the effect of the three types of interactions on SAP in Saudi Public University. The method used was a survey study with a total sample size of 216 participants of experimental group and control group. The results have shown that the influence of interactions on SAP is significant. The predictors of interaction processes were contributed in improving SAP by explained variance of (BL=37 to TL=41), (BL=83 to TL=66) and (BL=53 to TL=41) of student, instructor, and content interactions in blended learning compared to traditional learning respectively. © 2018 IEEE.