Research on Cloud Computing (CC) adoption seems to be one of the less explored and examined topics in the Information Systems (IS) domains, particularly for Small and Medium-sized Enterprises (SMEs). Prior research on CC adoption does not appreciate the benefits of using Innovation Translation Approach. Instead, Essentialist Approach, a simplistic view of CC adoption which is based only on the technological characteristics of the innovation is prevalent. Thus, this study integrates the Technology-Organization-Environment framework as an IS adoption theory while Actor Network Theory as an Innovation Translation Approach in proposing the SMEs-CC adoption framework. © 2016 IEEE.