Research into environmentally favorable alternatives to conventional concrete, such as reengineering techniques and the recycling of industrial and agricultural waste, has increased dramatically over the past decade. This research intended to examine the potential benefits of utilizing wheat straw ash (WSA) and marble dust powder (MDP) as supplementary cementitious materials (SCM) in high-strength concrete (HSC). The intention is to decrease carbon dioxide emissions and the amount of Portland cement (PC) required. Concrete formulations containing 0, 15, 20, 30, and 40 by weight of MDP and WSA as SCM, respectively, were evaluated by using response surface methodology (RSM) modelling for multi-objective optimization. This research assessed the environmental ramifications of employing WSA and MDP as SCM in HSC. Specifically, it examined the impacts on embodied carbon and eco-strength efficiency. Cubical specimens underwent a series of tests to attain the desirable compressive strength of approximately 60 MPa after a period of 28 days. The workability of green concrete decreased as the proportion of WSA and MDP used as SCM increased, according to the study. The optimum compressive strength, flexural strength, splitting tensile strength, and modulus of elasticity of HSC was recorded by 68 MPa, 5.98 MPa, 4.25 MPa, and 40 GPa, at 15 of SCM (composed of 10 WSA and 5 MDP) at 28 days respectively. Using ANOVA, response prediction models were validated and developed with a confidence level of 95. In summary, the increased application of 20 WSA and 20 MDP as SCM in concrete leads to a 31.64 reduction in the carbon footprint of the material. © 2024 Elsevier B.V.