Modification with Conventional Surfactants to Improve a Lipid-Based Ionic-Liquid-Associated Transcutaneous Anticancer Vaccine

Uddin, S. and Islam, M.R. and Moshikur, R.M. and Wakabayashi, R. and Moniruzzaman, M. and Goto, M. (2023) Modification with Conventional Surfactants to Improve a Lipid-Based Ionic-Liquid-Associated Transcutaneous Anticancer Vaccine. Molecules, 28 (7).

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Abstract

Transcutaneous vaccination is one of the successful, affordable, and patient-friendly advanced immunization approaches because of the presence of multiple immune-responsive cell types in the skin. However, in the absence of a preferable facilitator, the skin�s outer layer is a strong impediment to delivering biologically active foreign particles. Lipid-based biocompatible ionic-liquid-mediated nanodrug carriers represent an expedient and distinct strategy to permit transdermal drug delivery; with acceptable surfactants, the performance of drug formulations might be further enhanced. For this purpose, we formulated a lipid-based nanovaccine using a conventional (cationic/anionic/nonionic) surfactant loaded with an antigenic protein and immunomodulator in its core to promote drug delivery by penetrating the skin and boosting drug delivery and immunogenic cell activity. In a follow-up investigation, a freeze�dry emulsification process was used to prepare the nanovaccine, and its transdermal delivery, pharmacokinetic parameters, and ability to activate autoimmune cells in the tumor microenvironment were studied in a tumor-budding C57BL/6N mouse model. These analyses were performed using ELISA, nuclei and HE staining, flow cytometry, and other biological techniques. The immunomodulator-containing nanovaccine significantly (p < 0.001) increased transdermal drug delivery and anticancer immune responses (IgG, IgG1, IgG2, CD8+, CD207+, and CD103+ expression) without causing cellular or biological toxicity. Using a nanovaccination approach, it is possible to create a more targeted and efficient delivery system for cancer antigens, thereby stimulating a stronger immune response compared with conventional aqueous formulations. This might lead to more effective therapeutic and preventative outcomes for patients with cancer. © 2023 by the authors.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: antigen; immunological adjuvant; lipid; surfactant; vaccine, animal; C57BL mouse; cutaneous drug administration; drug delivery system; mouse, Adjuvants, Immunologic; Administration, Cutaneous; Animals; Antigens; Drug Delivery Systems; Lipids; Mice; Mice, Inbred C57BL; Surface-Active Agents; Vaccines
Depositing User: Mr Ahmad Suhairi UTP
Date Deposited: 04 Jun 2024 14:11
Last Modified: 04 Jun 2024 14:11
URI: https://khub.utp.edu.my/scholars/id/eprint/18666

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