This chapter propelled a transparent model or road map to start a new business venture that addresses literature and practices. The study aimed to investigate the serial mediation of opportunity creation, opportunity discovery, and entrepreneurial recognition between the relationship of entrepreneurial Alertness and new venture creation through the authority of entrepreneurship theory. The post-positivist school of thought has followed to unfold the current phenomenon. The study used the online survey forum of Google Forms and sent the link to the respondents through e-mail. The quantitative research method was implemented, and data were collected through stratified random sampling-the sample of 575 responses was collected from 54 Universities in South Asia and South Europe. The one-shot serial mediation model has run through user-defined in AMOS version 26. A partial serial mediation has been reported in the results of the study. All six hypotheses resulted in significant relationships. © 2023, IGI Global.