Our healthcare system nowadays is far more advanced from what we are twenty years ago. Adding to that, healthcare system is moving towards computerization and informative era. At this moment, implementation of Knowledge Management (KM) within healthcare system is very popular and motivating subject to focus. This paper listed and discussed two challenges faced by the Malaysian healthcare system, followed with the state of the art of the combination of KM and IT within healthcare system. The main KM mechanism focused in this paper is knowledge integration and knowledge sharing. We believe the successful of knowledge integration lead to opening the door to knowledge sharing. As the result, we suggested a theoretical framework for healthcare portal in Malaysia to encourage knowledge sharing using a case study scenario. © 2011 IEEE.