This chapter focuses on the various additives used by conventional techniques to treat wastewater. It also gives an overview of the favorable conditions to determine the hydrate formers in the hydrate-based desalination process. Using additives to enhance hydrate formation has been proven as an effective technique to advance the use of hydrate technology during the last two decades, and typically consists of kinetic promoters and thermodynamic promoters. It gives insights into the potential hydrate formers for hydrate-based desalination that can enhance the rate of hydrate formation. © 2022 John Wiley & Sons, Inc.