This chapter explains the thermodynamic phase equilibrium and kinetic modeling of hydrate formation in seawater through the gas hydrate-based desalination process. The literature review of the proposed models reveals that the production of gas hydrate is affected not only by gas composition and free water concentration, but also by temperature and pressure. Further application of artificial intelligence in desalination efficiency is also discussed. A literature review based on kinetic models for hydrate formation has been discussed. Hybrid machine learning techniques are suggested for finding the optimum process parameters, such as pollutant removal efficiency and higher water recovery. © 2022 John Wiley & Sons, Inc.