Most cellulose triacetate (CTA)-based studies for forward osmosis (FO) have greatly focused on achieving asymmetric membranes with a highly porous sublayer along with a dense selective layer. Such membranes can achieve better fluxes due to improved mass transfer and reduced internal concentration polarization. In this work, patterning of the CTA-membranes via modification of the conventional non-solvent induced phase inversion is explored as an alternative route to increase FO water flux without reducing salt selectivity. The modified way of applying the non-solvent in this method increased the membrane bulk porosity from ~17 to ~50 . Such high porosity and reduced tortuosity of the patterned membrane can reduce the internal concentration polarization by back-transport and reduced accumulation of salt and other solutes in the porous support. During FO, the patterned CTA membrane showed a water flux of 30 L m�2 h�1 and reverse salt flux of 25 g m�2 h�1, thanks to the increased effective membrane area, low water transport resistance, and high porosity of the membrane support. The patterned CTA-membranes may have potential in FO for applications with larger draw solutes due to the slightly larger pores on the membrane surface following the non-solvent spraying. Alternatively, some phase inversion parameters can still be further tuned to lower the salt passage. © 2022