Novel La-Ce-TiO2 photocatalysts were successfully synthesized via a facile sonochemical-assisted synthesis method. The photocatalytic degradation of the amoxicillin antibiotic was investigated via the addition of rare-earth metals, namely Lanthanum and Cerium nanoparticles as cocatalysts on the surface of TiO2. The synergistic interaction between La and Ce nanoparticles loaded on the TiO2 shows a profound activity as the amoxicillin removal via La-Ce-TiO2 photocatalyst was double than the pure TiO2 sample. Obviously, the sonochemical-assisted method played an important role in minimizing the particles aggregation and thus improving the photocatalytic activity. © Malaysian Journal of Microscopy (2020). All rights reserved.