The chapter aims at analyzing the impact of induced-mood states on working-memory functions of the prefrontal cortex. We would like to propose functional near-infrared spectroscopy (fNIRS) as alternative neuroimaging modality for functional magnetic resonance imaging to allow a more naturalistic settings. fNIRS allows the subject to sit comfortably (neuroergonomics) and therefore it is less likely to randomly modulate the subject�s emotion, suitable for study related to psychology. 31 participants were chosen to undergo the n-back task paradigm and the results were recorded. © 2018 Elsevier Inc. All rights reserved.