Constitutively active canonical NF-κB pathway induces severe bone loss in mice.

by Jesse E Otero, Tim Chen, Kaihua Zhang, Yousef Abu-Amer
Published 2012-01-01

IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology

by Manoj Arra, Gaurav Swarnkar, Yael Alippe, Gabriel Mbalaviele, Yousef Abu-Amer
Published 2022-02-01

Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.

by Gaurav Swarnkar, Kaihua Zhang, Gabriel Mbalaviele, Fanxin Long, Yousef Abu-Amer
Published 2014-01-01

Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB

by Gretchen A Meyer, Stavros Thomopoulos, Yousef Abu-Amer, Karen C Shen
Published 2022-12-01

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

by Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu-Amer, Gabriel Mbalaviele
Published 2024-04-01

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis

by Jianqiu Xiao, Kai Sun, Chun Wang, Yousef Abu-Amer, Gabriel Mbalaviele
Published 2022-01-01

Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

by Naga Suresh Adapala, Gaurav Swarnkar, Manoj Arra, Jie Shen, Gabriel Mbalaviele, Ke Ke, Yousef Abu-Amer
Published 2020-03-01

Targeting angiogenesis for fracture nonunion treatment in inflammatory disease

by Cuicui Wang, Jun Ying, Xiaolei Nie, Tianhong Zhou, Ding Xiao, Gaurav Swarnkar, Yousef Abu-Amer, Jianjun Guan, Jie Shen
Published 2021-06-01

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells

by Chun Wang, Can-Xin Xu, Yael Alippe, Chao Qu, Jianqiu Xiao, Ernestina Schipani, Roberto Civitelli, Yousef Abu-Amer, Gabriel Mbalaviele
Published 2017-07-01

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

by Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V. Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele
Published 2017-07-01

Glutamine metabolism modulates chondrocyte inflammatory response

by Manoj Arra, Gaurav Swarnkar, Naga Suresh Adapala, Syeda Kanwal Naqvi, Lei Cai, Muhammad Farooq Rai, Srikanth Singamaneni, Gabriel Mbalaviele, Robert Brophy, Yousef Abu-Amer
Published 2022-08-01

Isoflurane Conditioning Provides Protection against Subarachnoid Hemorrhage Induced Delayed Cerebral Ischemia through NF-kB Inhibition

by Meizi Liu, Keshav Jayaraman, Jogender Mehla, Deepti Diwan, James W. Nelson, Ahmed E. Hussein, Ananth K. Vellimana, Yousef Abu-Amer, Gregory J. Zipfel, Umeshkumar Athiraman
Published 2023-04-01

Isoflurane Conditioning‐Induced Delayed Cerebral Ischemia Protection in Subarachnoid Hemorrhage—Role of Inducible Nitric Oxide Synthase

by Meizi Liu, Keshav Jayaraman, Aaron J. Norris, Ahmed Hussein, James W. Nelson, Jogender Mehla, Deepti Diwan, Ananth Vellimana, Yousef Abu‐Amer, Gregory J. Zipfel, Umeshkumar Athiraman
Published 2023-07-01

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.

by Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Canxin Xu, Dustin Kress, Roberto Civitelli, Yousef Abu-Amer, Thirumala-Devi Kanneganti, Daniel C Link, Gabriel Mbalaviele
Published 2018-11-01

Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling

by Kai Sun, Chun Wang, Jianqiu Xiao, Michael D Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J Silva, Jie Shen, Gabriel Mbalaviele
Published 2022-03-01

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

by Manoj Arra, Gaurav Swarnkar, Ke Ke, Jesse E. Otero, Jun Ying, Xin Duan, Takashi Maruyama, Muhammad Farooq Rai, Regis J. O’Keefe, Gabriel Mbalaviele, Jie Shen, Yousef Abu-Amer
Published 2020-07-01

Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.

by Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L Kostecki, Joseph B Monahan, Deborah J Veis, Yousef Abu-Amer, Daniel C Link, Gabriel Mbalaviele
Published 2020-08-01

Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes

by Tong Yang, Kai Sun, Chun Wang, Gaurav Swarnkar, Songtao Quan, Dustin Kress, Jianqiu Xiao, Yael Alippe, Hongjun Zheng, Robert H Brophy, Dingjun Hao, Audrey McAlinden, Yousef Abu-Amer, Jie Shen, Gabriel Mbalaviele
Published 2021-11-01