DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation

by Mitchell A. Pallett, Yongxu Lu, Geoffrey L. Smith
Published 2022-02-01

An Overview of Current Knowledge of Deadly CoVs and Their Interface with Innate Immunity

by Yamei Zhang, Siobhan Gargan, Yongxu Lu, Nigel J. Stevenson
Published 2021-03-01

Manipulation of innate immune signaling pathways by SARS-CoV-2 non-structural proteins

by Yongxu Lu, Hendrik A. Michel, Pei-Hui Wang, Geoffrey L. Smith
Published 2022-11-01

Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2.

by Jennifer H Stuart, Rebecca P Sumner, Yongxu Lu, Joseph S Snowden, Geoffrey L Smith
Published 2016-12-01

Editorial: Three-way interactions between host, environment, and microbiome: Importance of microbiology in the One Health

by Caihong Wu, Ruixin Zhu, Yongxu Lu, Dong Li, Yuan Xiao, Weiwei Cui, Na Li
Published 2023-03-01

HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus

by Yongxu Lu, Yiqi Zhao, Chen Gao, Shreehari Suresh, Jinghao Men, Amelia Sawyers, Geoffrey L. Smith
Published 2024-03-01

Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist

by Lior Soday, Yongxu Lu, Jonas D. Albarnaz, Colin T.R. Davies, Robin Antrobus, Geoffrey L. Smith, Michael P. Weekes
Published 2019-05-01

The nuclear localization signal of monkeypox virus protein P2 orthologue is critical for inhibition of IRF3-mediated innate immunity

by Pengtao Jiao, Jianing Ma, Yuna Zhao, Xiaoxiao Jia, Haoran Zhang, Wenhui Fan, Xiaojuan Jia, Xiaoyuan Bai, Yiqi Zhao, Yongxu Lu, He Zhang, Jiayin Guo, Gang Pang, Ke Zhang, Min Fang, Minghua Li, Wenjun Liu, Geoffrey L. Smith, Lei Sun
Published 2024-06-01

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

by Hazel Stewart, Yongxu Lu, Sarah O’Keefe, Anusha Valpadashi, Luis Daniel Cruz-Zaragoza, Hendrik A. Michel, Samantha K. Nguyen, George W. Carnell, Nina Lukhovitskaya, Rachel Milligan, Yasmin Adewusi, Irwin Jungreis, Valeria Lulla, David A. Matthews, Stephen High, Peter Rehling, Edward Emmott, Jonathan L. Heeney, Andrew D. Davidson, James R. Edgar, Geoffrey L. Smith, Andrew E. Firth
Published 2023-11-01

Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination

by Zixi Yin, Ji-Li Chen, Yongxu Lu, Beibei Wang, Leila Godfrey, Alexander J. Mentzer, Xuan Yao, Guihai Liu, Dannielle Wellington, Yiqi Zhao, Peter A.C. Wing, Wanwisa Dejnirattisa, Piyada Supasa, Chang Liu, Philip Hublitz, Ryan Beveridge, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Timothy Rostron, Juthathip Mongkolsapaya, Gavin R. Screaton, Graham Ogg, Katie Ewer, Andrew J. Pollard, Sarah Gilbert, Julian C. Knight, Teresa Lambe, Geoffrey L. Smith, Tao Dong, Yanchun Peng
Published 2023-05-01

Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.

by Lu, Yongxu, Stuart, Jennifer H, Talbot-Cooper, Callum, Agrawal-Singh, Shuchi, Huntly, Brian, Smid, Andrei I, Snowden, Joseph S, Dupont, Liane, Smith, Geoffrey L
Published 2019