Lipid-based nanoparticles and RNA as innovative neuro-therapeutics

by Maria Tsakiri, Cristina Zivko, Cristina Zivko, Costas Demetzos, Vasiliki Mahairaki, Vasiliki Mahairaki
Published 2022-08-01

Stem cell-derived three-dimensional (organoid) models of Alzheimer’s disease: a precision medicine approach

by Sujung Jun Kim, Jiaxin Li, Vasiliki Mahairaki
Published 2021-01-01

Lipidic Nanoparticles, Extracellular Vesicles and Hybrid Platforms as Advanced Medicinal Products: Future Therapeutic Prospects for Neurodegenerative Diseases

by Maria Tsakiri, Ioannis Tsichlis, Cristina Zivko, Costas Demetzos, Vasiliki Mahairaki
Published 2024-03-01

Generation and Characterization of a Human-Derived and Induced Pluripotent Stem Cell (iPSC) Line from an Alzheimer’s Disease Patient with Neuropsychiatric Symptoms

by Ram Sagar, Cristina Zivko, Ariadni Xydia, David C. Weisman, Constantine G. Lyketsos, Vasiliki Mahairaki
Published 2023-12-01

Generation and characterization of a novel human iPSC line from a resilient Alzheimer’s disease patient

by Debamitra Das, Jiaxin Li, Senquan Liu, Esther Oh, Linzhao Cheng, Constantine Lyketsos, Vasiliki Mahairaki
Published 2020-10-01

The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model

by Moriah E. Katt, Lakyn N. Mayo, Shannon E. Ellis, Vasiliki Mahairaki, Jeffrey D. Rothstein, Linzhao Cheng, Peter C. Searson
Published 2019-07-01

Excitatory Neurons Derived from Human-Induced Pluripotent Stem Cells Show Transcriptomic Differences in Alzheimer’s Patients from Controls

by Ram Sagar, Ioannis Azoidis, Cristina Zivko, Ariadni Xydia, Esther S. Oh, Paul B. Rosenberg, Constantine G. Lyketsos, Vasiliki Mahairaki, Dimitrios Avramopoulos
Published 2023-08-01

Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer’s Disease

by Dimitrios Vlachakis, Eleni Papakonstantinou, Ram Sagar, Flora Bacopoulou, Themis Exarchos, Panos Kourouthanassis, Vasileios Karyotis, Panayiotis Vlamos, Constantine Lyketsos, Dimitrios Avramopoulos, Vasiliki Mahairaki
Published 2021-06-01

A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability.

by Paul W Burridge, Susan Thompson, Michal A Millrod, Seth Weinberg, Xuan Yuan, Ann Peters, Vasiliki Mahairaki, Vassilis E Koliatsos, Leslie Tung, Elias T Zambidis
Published 2011-04-01

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

by Carlos J. Nogueras-Ortiz, Vasiliki Mahairaki, Francheska Delgado-Peraza, Debamitra Das, Konstantinos Avgerinos, Erden Eren, Matthew Hentschel, Edward J. Goetzl, Mark P. Mattson, Dimitrios Kapogiannis
Published 2020-07-01

iPSCs from people with MS can differentiate into oligodendrocytes in a homeostatic but not an inflammatory milieu.

by Itzy E Morales Pantoja, Matthew D Smith, Labchan Rajbhandari, Linzhao Cheng, Yongxing Gao, Vasiliki Mahairaki, Arun Venkatesan, Peter A Calabresi, Kathryn C Fitzgerald, Katharine A Whartenby
Published 2020-01-01

Putative Autoantigen Leiomodin-1 Is Expressed in the Human Brain and in the Membrane Fraction of Newly Formed Neurons

by David W. Nauen, Michael C. Haffner, Juyun Kim, Qizhi Zheng, Hao Yin, Angelo M. DeMarzo, Vasiliki Mahairaki, Carlo Colantuoni, J. Geoffrey Pickering, Tory P. Johnson
Published 2020-12-01

Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles

by Yiyao Huang, Lesley Cheng, Andrey Turchinovich, Vasiliki Mahairaki, Juan C. Troncoso, Olga Pletniková, Norman J. Haughey, Laura J. Vella, Andrew F. Hill, Lei Zheng, Kenneth W. Witwer
Published 2020-01-01

Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina

by Tom Driedonks, Linglei Jiang, Bess Carlson, Zheng Han, Guanshu Liu, Suzanne E. Queen, Erin N. Shirk, Olesia Gololobova, Zhaohao Liao, Lyle H. Nyberg, Gabriela Lima, Liliia Paniushkina, Marta Garcia‐Contreras, Kayla Schonvisky, Natalie Castell, Mitchel Stover, Selena Guerrero‐Martin, Riley Richardson, Barbara Smith, Vasiliki Mahairaki, Charles P. Lai, Jessica M. Izzi, Eric K. Hutchinson, Kelly A. M. Pate, Kenneth W. Witwer
Published 2022-10-01

A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta variants

by Linglei Jiang, Tom A.P. Driedonks, Wouter S.P. Jong, Santosh Dhakal, H. Bart van den Berg van Saparoea, Ioannis Sitaras, Ruifeng Zhou, Christopher Caputo, Kirsten Littlefield, Maggie Lowman, Mengfei Chen, Gabriela Lima, Olesia Gololobova, Barbara Smith, Vasiliki Mahairaki, M. Riley Richardson, Kathleen R. Mulka, Andrew P. Lane, Sabra L. Klein, Andrew Pekosz, Cory Brayton, Joseph L. Mankowski, Joen Luirink, Jason S. Villano, Kenneth W. Witwer
Published 2022-03-01

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop

by Ashley E. Russell, Alexandra Sneider, Kenneth W. Witwer, Paolo Bergese, Suvendra N. Bhattacharyya, Alexander Cocks, Emanuele Cocucci, Uta Erdbrügger, Juan M. Falcon-Perez, David W. Freeman, Thomas M. Gallagher, Shuaishuai Hu, Yiyao Huang, Steven M. Jay, Shin-ichi Kano, Gregory Lavieu, Aleksandra Leszczynska, Alicia M. Llorente, Quan Lu, Vasiliki Mahairaki, Dillon C. Muth, Nicole Noren Hooten, Matias Ostrowski, Ilaria Prada, Susmita Sahoo, Tine Hiorth Schøyen, Lifu Sheng, Deanna Tesch, Guillaume Van Niel, Roosmarijn E. Vandenbroucke, Frederik J. Verweij, Ana V. Villar, Marca Wauben, Ann M. Wehman, Hang Yin, David Raul Francisco Carter, Pieter Vader
Published 2019-12-01