MMP-15 is upregulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin.

by Tu'uhevaha J Kaitu'u-Lino, Kirsten Palmer, Laura Tuohey, Louie Ye, Stephen Tong
Published 2012-01-01

Serum concentrations of soluble Flt-1 are decreased among women with a viable fetus and no symptoms of miscarriage destined for pregnancy loss.

by Tu'uhevaha J Kaitu'u-Lino, Clare L Whitehead, Gene-Lyn Ngian, Michael Permezel, Stephen Tong
Published 2012-01-01

Plasma MIC-1 and PAPP-a levels are decreased among women presenting to an early pregnancy assessment unit, have fetal viability confirmed but later miscarry.

by Tu'uhevaha J Kaitu'u-Lino, Katerina Bambang, Joseph Onwude, Richard Hiscock, Justin Konje, Stephen Tong
Published 2013-01-01

A bioplex analysis of cytokines and chemokines in first trimester maternal plasma to screen for predictors of miscarriage.

by Natalie J Hannan, Katerina Bambang, Tu'uhevaha J Kaitu'u-Lino, Justin C Konje, Stephen Tong
Published 2014-01-01

Clinical tools and biomarkers to predict preeclampsia

by Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino
Published 2022-01-01

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dy...

by Natalie J Hannan, Natalie K Binder, Sally Beard, Tuong-Vi Nguyen, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong
Published 2018-01-01

Placental Growth Factor Is Secreted by the Human Endometrium and Has Potential Important Functions during Embryo Development and Implantation.

by Natalie K Binder, Jemma Evans, Lois A Salamonsen, David K Gardner, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan
Published 2016-01-01

Assessment of the Proton Pump Inhibitor, Esomeprazole Magnesium Hydrate and Trihydrate, on Pathophysiological Markers of Preeclampsia in Preclinical Human Models of Disease

by Natasha de Alwis, Bianca R. Fato, Sally Beard, Natalie K. Binder, Tu’uhevaha J. Kaitu’u-Lino, Kenji Onda, Natalie J. Hannan
Published 2022-08-01

Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infantResearch in context

by Lucy A. Bartho, Emerson Keenan, Susan P. Walker, Teresa M. MacDonald, Brunda Nijagal, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Published 2023-08-01

The Regulation of Endothelin-1 in Pregnancies Complicated by Gestational Diabetes: Uncovering the Vascular Effects of Insulin

by Bianca R. Fato, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Natasha de Alwis, Natalie J. Hannan
Published 2023-09-01

Investigating the Effects of Atrial Natriuretic Peptide on the Maternal Endothelium to Determine Potential Implications for Preeclampsia

by Natalie K. Binder, Sally Beard, Natasha de Alwis, Bianca R. Fato, Tuong-Vi Nguyen, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Published 2023-03-01

Pre-Clinical Investigation of Cardioprotective Beta-Blockers as a Therapeutic Strategy for Preeclampsia

by Natalie K. Binder, Teresa M. MacDonald, Sally A. Beard, Natasha de Alwis, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Published 2021-07-01

Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries—A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development

by Bianca R. Fato, Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Published 2022-09-01

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.

by Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Sally Beard, Ping Cannon, Roxanne Hastie, Tuong V Nguyen, Natalie K Binder, Stephen Tong, Natalie J Hannan
Published 2018-01-01

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction – implications as a preeclampsia treatment

by Natalie J. Hannan, Fiona C. Brownfoot, Ping Cannon, Minh Deo, Sally Beard, Tuong V. Nguyen, Kirsten R. Palmer, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino
Published 2017-05-01

Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy

by Roxanne Hastie, Elgene Lim, Pavel Sluka, Lisa Campbell, Andrew W. Horne, Lenore Ellett, Natalie J. Hannan, Fiona Brownfoot, Tu'uhevaha J. Kaitu'u-Lino, Stephen Tong
Published 2018-03-01

Placental galectin-3 is reduced in early-onset preeclampsia

by Manju Kandel, Manju Kandel, Stephen Tong, Stephen Tong, Susan P Walker, Susan P Walker, Ping Cannon, Ping Cannon, Tuong-Vi Nguyen, Tuong-Vi Nguyen, Teresa M. MacDonald, Teresa M. MacDonald, Natalie J. Hannan, Natalie J. Hannan, Tu’uhevaha J. Kaitu’u-Lino, Tu’uhevaha J. Kaitu’u-Lino, Lucy A Bartho, Lucy A Bartho
Published 2022-10-01

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunctionResearch in context

by Fiona C. Brownfoot, Natalie J. Hannan, Ping Cannon, Vi Nguyen, Roxanne Hastie, Laura J. Parry, Sevvandi Senadheera, Laura Tuohey, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Published 2019-03-01

Assessment of the tocolytic nifedipine in preclinical primary models of preterm birth

by Bridget M. Arman, Natalie K. Binder, Natasha de Alwis, Sally Beard, Danielle A. Debruin, Alan Hayes, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Published 2023-04-01

Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial

by Ben W Mol, Henrik Imberg, Susan P Walker, David Hall, Tu’uhevaha J Kaitu’u-Lino, Stephen Tong, Adrie Bekker, Lina Bergman, Adrienne Gordon, Fiona Brownfoot, Catherine Anne Cluver
Published 2024-06-01