Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 h...

by Torres Manuel, Jimenez Sebastian, Sanchez-Varo Raquel, Navarro Victoria, Trujillo-Estrada Laura, Sanchez-Mejias Elisabeth, Carmona Irene, Davila Jose Carlos, Vizuete Marisa, Gutierrez Antonia, Vitorica Javier
Published 2012-11-01

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer¿s disease pathology

by Trujillo-Estrada, Laura, Jimenez, Sebastian, De Castro, Vanessa, Torres, Manuel, Baglietto-Vargas, David, Moreno-Gonzalez, Ines, Navarro, Victoria, Sanchez-Varo, Raquel, Sanchez-Mejias, Elisabeth, Davila, Jose, Vizuete, Marisa, Gutierrez, Antonia, Vitorica, Javier
Published 2013

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimers Disease.

by Trujillo-Estrada, Laura, Vanderklish, Peter, Nguyen, Marie, Kuang, Run, Nguyen, Caroline, Huynh, Eric, da Cunha, Celia, Javonillo, Dominic, Forner, Stefania, Martini, Alessandra, Sarraf, Stella, Simmon, Vincent, Baglietto-Vargas, David, Laferla, Frank
Published 2021

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.

by Baglietto-Vargas, David, Prieto, Gilberto Aleph, Limon, Agenor, Forner, Stefania, Rodriguez-Ortiz, Carlos J, Ikemura, Kenji, Ager, Rahasson R, Medeiros, Rodrigo, Trujillo-Estrada, Laura, Martini, Alessandra C, Kitazawa, Masashi, Davila, Jose C, Cotman, Carl W, Gutierrez, Antonia, LaFerla, Frank M
Published 2018

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

by Trujillo-Estrada, Laura, Nguyen, Cassidy, da Cunha, Celia, Cai, Lena, Forner, Stefania, Martini, Alessandra C, Ager, Rahasson R, Prieto, Gilberto Aleph, Cotman, Carl W, Baglietto-Vargas, David, LaFerla, Frank M
Published 2019

miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.

by Rodriguez-Ortiz, Carlos J, Prieto, Gilberto Aleph, Martini, Alessandra C, Forner, Stefania, Trujillo-Estrada, Laura, LaFerla, Frank M, Baglietto-Vargas, David, Cotman, Carl W, Kitazawa, Masashi
Published 2020