A targeted amplicon next-generation sequencing assay for tryptase genotyping to support personalized therapy in mast cell-related disorders.

by Olga Li, Jason A Hackney, David F Choy, Diana Chang, Rhea Nersesian, Tracy L Staton, Fang Cai, Shadi Toghi Eshghi
Published 2024-01-01

A phase I, randomized, observer-blinded, single and multiple ascending-dose study to investigate the safety, pharmacokinetics, and immunogenicity of BITS7201A, a bispecific antibod...

by Tracy L. Staton, Kun Peng, Ryan Owen, David F. Choy, Christopher R. Cabanski, Alice Fong, Flavia Brunstein, Kathila R. Alatsis, Hubert Chen
Published 2019-01-01

A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma

by Sharon M. Rymut, Lindsay M. Henderson, Victor Poon, Tracy L. Staton, Fang Cai, Siddharth Sukumaran, Horace Rhee, Ryan Owen, Saroja Ramanujan, Kenta Yoshida
Published 2023-04-01

Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial

by Sharon M. Rymut, Siddharth Sukumaran, Gizette Sperinde, Meire Bremer, Joshua Galanter, Kenta Yoshida, Jordan Smith, Prajna Banerjee, Viyia Sverkos, Fang Cai, Verena Steffen, Lindsay M. Henderson, Horace Rhee, Paula N. Belloni, Joseph H. Lin, Tracy L. Staton
Published 2022-02-01

A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk

by Diana Chang, Julie Hunkapiller, Tushar Bhangale, Jens Reeder, Kiran Mukhyala, Jennifer Tom, Amy Cowgill, Jan Vogel, William F. Forrest, Zia Khan, Amy Stockwell, Mark I. McCarthy, Tracy L. Staton, Julie Olsson, Cecile T. J. Holweg, Dorothy S. Cheung, Hubert Chen, Matthew J. Brauer, Robert R. Graham, Timothy Behrens, Mark S. Wilson, Joseph R. Arron, David F. Choy, Brian L. Yaspan
Published 2022-04-01