RefPlantNLR is a comprehensive collection of experimentally validated plant disease resistance proteins from the NLR family.

by Jiorgos Kourelis, Toshiyuki Sakai, Hiroaki Adachi, Sophien Kamoun
Published 2021-10-01

Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells.

by Masami Ichikawa, Yoshihiro Sowa, Yosuke Iizumi, Yuichi Aono, Toshiyuki Sakai
Published 2015-01-01

Smenospongine, a Sesquiterpene Aminoquinone from a Marine Sponge, Induces G1 Arrest or Apoptosis in Different Leukemia Cells

by Motomasa Kobayashi, Toshiyuki Sakai, Yoshihiro Sowa, Shunji Aoki, Dexin Kong
Published 2008-08-01

The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells.

by Makoto Wada, Mano Horinaka, Toshikazu Yamazaki, Norito Katoh, Toshiyuki Sakai
Published 2014-01-01

Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells.

by Ryoichi Tanaka, Mitsuhiro Tomosugi, Mano Horinaka, Yoshihiro Sowa, Toshiyuki Sakai
Published 2015-01-01

Relationship Between Spatial Distribution of Sika Deer–Train Collisions and Sika Deer Movement in Japan

by Akinao Soga, Shin-ichiro Hamasaki, Noriko Yokoyama, Toshiyuki Sakai, Koichi Kaji
Published 2017-02-01

Whole-genome analysis of recombinant inbred rice lines reveals a quantitative trait locus on chromosome 3 with genotype-by-environment interaction effects

by Toshiyuki Sakai, Tomoaki Fujioka, Toyokazu Uemura, Shinichi Saito, Ryohei Terauchi, Akira Abe
Published 2023-04-01

The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal protein S9.

by Yosuke Iizumi, Masakatsu Oishi, Tomoyuki Taniguchi, Wakana Goi, Yoshihiro Sowa, Toshiyuki Sakai
Published 2013-01-01

Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2.

by Masakatsu Oishi, Yosuke Iizumi, Tomoyuki Taniguchi, Wakana Goi, Tsuneharu Miki, Toshiyuki Sakai
Published 2013-01-01

Identification of c-Met as a novel target of γ-glutamylcyclotransferase

by Yumiko Saito, Keiko Taniguchi, Hiromi Ii, Mano Horinaka, Susumu Kageyama, Susumu Nakata, Osamu Ukimura, Toshiyuki Sakai
Published 2023-07-01

The Combination of Cigarette Smoking and Alcohol Consumption Synergistically Increases Reactive Carbonyl Species in Human Male Plasma

by Kanae Mure, Susumu Tomono, Minae Mure, Mano Horinaka, Michihiro Mutoh, Toshiyuki Sakai, Hideki Ishikawa, Keiji Wakabayashi
Published 2021-08-01

Discovery of cancer-preventive juices reactivating RB functions

by Mitsuharu Masuda, Mano Horinaka, Shusuke Yasuda, Mie Morita, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai
Published 2023-09-01

Very Long-Term Treatment with a <i>Lactobacillus</i> Probiotic Preparation, <i>Lactobacillus Casei</i> Strain Shirota, Suppresses Weight Loss in the Elderly

by Hideki Ishikawa, Michihiro Mutoh, Kenichi Yoshimura, Gen Fujii, Tomiyo Nakamura, Tatsuya Takeshita, Keiji Wakabayashi, Toshiyuki Sakai
Published 2020-05-01

Deactivation of Glutaminolysis Sensitizes <i>PIK3CA</i>-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition

by Shogen Boku, Motoki Watanabe, Mamiko Sukeno, Takeshi Yaoi, Kiichi Hirota, Mahiro Iizuka-Ohashi, Kyoko Itoh, Toshiyuki Sakai
Published 2020-04-01

xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner

by Keiko Miyamoto, Motoki Watanabe, Shogen Boku, Mamiko Sukeno, Mie Morita, Haruhito Kondo, Koichi Sakaguchi, Tetsuya Taguchi, Toshiyuki Sakai
Published 2020-03-01

Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol

by Yosuke Iizumi, Yoshihiro Sowa, Wakana Goi, Yuichi Aono, Motoki Watanabe, Yoichi Kurumida, Tomoshi Kameda, Kenichi Akaji, Masatoshi Kitagawa, Toshiyuki Sakai
Published 2022-06-01

Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2

by Motoki Watanabe, Yasumasa Yamada, Yoichi Kurumida, Tomoshi Kameda, Mamiko Sukeno, Mahiro Iizuka-Ohashi, Yoshihiro Sowa, Yosuke Iizumi, Hideki Takakura, Shingo Miyamoto, Toshiyuki Sakai, Michihiro Mutoh
Published 2021-02-01

An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana

by Hiroaki Adachi, Toshiyuki Sakai, Adeline Harant, Hsuan Pai, Kodai Honda, AmirAli Toghani, Jules Claeys, Cian Duggan, Tolga O. Bozkurt, Chih-hang Wu, Sophien Kamoun
Published 2023-01-01

An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana.

by Hiroaki Adachi, Toshiyuki Sakai, Adeline Harant, Hsuan Pai, Kodai Honda, AmirAli Toghani, Jules Claeys, Cian Duggan, Tolga O Bozkurt, Chih-Hang Wu, Sophien Kamoun
Published 2023-01-01

p53 inactivation upregulates p73 expression through E2F-1 mediated transcription.

by Chaitali Tophkhane, Shi-He Yang, Yunbo Jiang, Zhikun Ma, Dharmalingam Subramaniam, Shrikant Anant, Shingo Yogosawa, Toshiyuki Sakai, Wan-Guo Liu, Susan Edgerton, Ann Thor, Xiaohe Yang
Published 2012-01-01