A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.

by Sng, Christopher CT, O'Byrne, Sorcha, Prigozhin, Daniil M, Bauer, Matthias R, Harvey, Jennifer C, Ruhle, Michelle, Challis, Ben G, Lear, Sara, Roberts, Lee D, Workman, Sarita, Janowitz, Tobias, Magiera, Lukasz, Doffinger, Rainer, Buckland, Matthew S, Jodrell, Duncan J, Semple, Robert K, Wilson, Timothy J, Modis, Yorgo, Thaventhiran, James ED
Published 2018

A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection.

by Gerber, Pehuén Pereyra, Duncan, Lidia M, Greenwood, Edward Jd, Marelli, Sara, Naamati, Adi, Teixeira-Silva, Ana, Crozier, Thomas Wm, Gabaev, Ildar, Zhan, Jun R, Mulroney, Thomas E, Horner, Emily C, Doffinger, Rainer, Willis, Anne, Thaventhiran, James Ed, Protasio, Anna, Matheson, Nicholas
Published 2022

Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

by Cytlak, Urszula, Resteu, Anastasia, Pagan, Sarah, Green, Kile, Milne, Paul, Maisuria, Sheetal, McDonald, David, Hulme, Gillian, Filby, Andrew, Carpenter, Benjamin, Queen, Rachel, Hambleton, Sophie, Hague, Rosie, Lango Allen, Hana, Thaventhiran, James ED, Doody, Gina, Collin, Matthew, Bigley, Venetia
Published 2020

A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection.

by Gerber, Pehuén Pereyra, Duncan, Lidia M, Greenwood, Edward Jd, Marelli, Sara, Naamati, Adi, Teixeira-Silva, Ana, Crozier, Thomas Wm, Gabaev, Ildar, Zhan, Jun R, Mulroney, Thomas E, Horner, Emily C, Doffinger, Rainer, Willis, Anne E, Thaventhiran, James Ed, Protasio, Anna V, Matheson, Nicholas J
Published 2022

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.

by Bergamaschi, Laura, Mescia, Federica, Turner, Lorinda, Hanson, Aimee L, Kotagiri, Prasanti, Dunmore, Benjamin J, Ruffieux, Hélène, De Sa, Aloka, Huhn, Oisín, Morgan, Michael D, Gerber, Pehuen Pereyra, Wills, Mark R, Baker, Stephen, Calero‐Nieto, Fernando J, Doffinger, Rainer, Dougan, Gordon, Elmer, Anne, Goodfellow, Ian G, Gupta, Ravindra K, Hosmillo, Myra, Hunter, Kelvin, Kingston, Nathalie, Lehner, Paul J, Matheson, Nicholas J, Nicholson, Jeremy K, Petrunkina, Anna M, Richardson, Sylvia, Saunders, Caroline, Thaventhiran, James ED, Toonen, Erik JM, Weekes, Michael P, Göttgens, Berthold, Toshner, Mark, Hess, Christoph, Bradley, John R, Lyons, Paul A, Smith, Kenneth GC
Published 2021

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.

by Sng, Christopher CT, O'Byrne, Sorcha, Prigozhin, Daniil M, Bauer, Matthias R, Harvey, Jennifer C, Ruhle, Michelle, Challis, Ben G, Lear, Sara, Roberts, Lee D, Workman, Sarita, Janowitz, Tobias, Magiera, Lukasz, Doffinger, Rainer, Buckland, Matthew S, Jodrell, Duncan J, Semple, Robert K, Wilson, Timothy J, Modis, Yorgo, Thaventhiran, James ED
Published 2018

ADA2 deficiency complicated by EBV-driven lymphoproliferative disease.

by Staples, Emily, Simeoni, Ilenia, Stephens, Jonathan C, Allen, Hana Lango, NIHR-BioResource, Wright, Penny, Davies, E Graham, Javid, Babak, Gkrania-Klotsas, Effrossyni, Gattens, Michael, Firth, Helen, Shamardina, Olga, Deevi, Sri VV, Prapa, Matina, Uttenthal, Ben, Kumararatne, Dinakantha, Thaventhiran, James ED
Published 2020

CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response.

by Biasci, Daniele, Smoragiewicz, Martin, Connell, Claire M, Wang, Zhikai, Gao, Ya, Thaventhiran, James ED, Basu, Bristi, Magiera, Lukasz, Johnson, T Isaac, Bax, Lisa, Gopinathan, Aarthi, Isherwood, Christopher, Gallagher, Ferdia A, Pawula, Maria, Hudecova, Irena, Gale, Davina, Rosenfeld, Nitzan, Barmpounakis, Petros, Popa, Elizabeta Cristina, Brais, Rebecca, Godfrey, Edmund, Mir, Fraz, Richards, Frances M, Fearon, Douglas T, Janowitz, Tobias, Jodrell, Duncan I
Published 2020

SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings from the COV-AD Study.

by Shields, Adrian M, Faustini, Sian E, Hill, Harriet J, Al-Taei, Saly, Tanner, Chloe, Ashford, Fiona, Workman, Sarita, Moreira, Fernando, Verma, Nisha, Wagg, Hollie, Heritage, Gail, Campton, Naomi, Stamataki, Zania, Klenerman, Paul, Thaventhiran, James ED, Goddard, Sarah, Johnston, Sarah, Huissoon, Aarnoud, Bethune, Claire, Elcombe, Suzanne, Lowe, David M, Patel, Smita Y, Savic, Sinisa, Burns, Siobhan O, Richter, Alex G, COV-AD consortium
Published 2022

Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation: An Update From the COV-AD Study.

by Shields, Adrian M, Faustini, Sian E, Hill, Harriet J, Al-Taei, Saly, Tanner, Chloe, Ashford, Fiona, Workman, Sarita, Moreira, Fernando, Verma, Nisha, Wagg, Hollie, Heritage, Gail, Campton, Naomi, Stamataki, Zania, Drayson, Mark T, Klenerman, Paul, Thaventhiran, James ED, Elkhalifa, Shuayb, Goddard, Sarah, Johnston, Sarah, Huissoon, Aarnoud, Bethune, Claire, Elcombe, Suzanne, Lowe, David M, Patel, Smita Y, Savic, Sinisa, Richter, Alex G, Burns, Siobhan O, COV-AD consortium
Published 2022

Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection

by Jones, Nick K, Rivett, Lucy, Seaman, Shaun, Samworth, Richard J, Warne, Ben, Workman, Chris, Ferris, Mark, Wright, Jo, Quinnell, Natalie, Shaw, Ashley, Cambridge COVID-19 Collaboration, Goodfellow, Ian G, Lehner, Paul J, Howes, Rob, Wright, Giles, Matheson, Nicholas J, Weekes, Michael P, Amory, Amy, Baker, Stephen, Bateman, Emma, Begum, Aklima, Begum, Moushima, Bradley, John, Brennan, Michael, Burn, Helen, Crofts, Caroline, Chaudhry, Afzal, Chaudhry, Yasmin, Cooper, Daniel J, Dawson, Sharon, Dougan, Gordon, Feather, Renny, Free, Louise, Friel, Katie, Gildea, Claire, Georgana, Iliana, Grimwade, Lizz, Gupta, Ravi, Hall, Susan, Hannan, Sophie, Hayes, James, Hosaja, Aleksandra, Hosmillo, Myra, Izuagbe, Rhys, Jahun, Aminu, James, Lidia, Jardin, Jill, Kingston, Nathalie, Lear, Sara, Lyons, Paul A, Maxwell, Patrick H, Mott, Sue, Mugavin, Sarah, Mwiya, Joyce, Peacock, Sharon, Nallattil, Ravi Prakash, Oloyede, Kazeem, Ouwehand, Willem H, Page, Elle, Perez, Marina, Raine, Tim, Routledge, Matthew, Saunders, Caroline, Smith, Kenneth GC, Sparkes, Dominic, Stafford, Maria, Summers, Charlotte, Tatsi, Despiona, Thaventhiran, James ED, Thomas Johnson, Sharon, Török, M Estée, Toshner, Mark, Turner, Lesley, Wall, Kate, Watson, Karis
Published 2021

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report.

by Buckland, Matthew S, Galloway, James B, Fhogartaigh, Caoimhe Nic, Meredith, Luke, Provine, Nicholas M, Bloor, Stuart, Ogbe, Ane, Zelek, Wioleta M, Smielewska, Anna, Yakovleva, Anna, Mann, Tiffeney, Bergamaschi, Laura, Turner, Lorinda, Mescia, Frederica, Toonen, Erik JM, Hackstein, Carl-Philipp, Akther, Hossain Delowar, Vieira, Vinicius Adriano, Ceron-Gutierrez, Lourdes, Periselneris, Jimstan, Kiani-Alikhan, Sorena, Grigoriadou, Sofia, Vaghela, Devan, Lear, Sara E, Török, M Estée, Hamilton, William L, Stockton, Joanne, Quick, Josh, Nelson, Peter, Hunter, Michael, Coulter, Tanya I, Devlin, Lisa, CITIID-NIHR COVID-19 BioResource Collaboration, MRC-Toxicology Unit COVID-19 Consortium, Bradley, John R, Smith, Kenneth GC, Ouwehand, Willem H, Estcourt, Lise, Harvala, Heli, Roberts, David J, Wilkinson, Ian B, Screaton, Nick, Loman, Nicholas, Doffinger, Rainer, Lyons, Paul A, Morgan, B Paul, Goodfellow, Ian G, Klenerman, Paul, Lehner, Paul J, Matheson, Nicholas J, Thaventhiran, James ED
Published 2020